Synapse News and Research

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Patient-specific muscle models pave way for personalized neuromuscular therapies

Scientists have so far identified around 800 different neuromuscular diseases. These conditions are caused by problems in the way muscle cells, motor neurons and peripheral cells interact.

19 Dec 2023

What's my age again? Predicting disease and aging effects by studying organ aging using plasma proteomics data

Researchers performed a proteomic analysis to identify serologic indicators of organ aging and disease.

7 Dec 2023

IU researchers uncover novel mechanism of pathogen entry into cells

Similar to a burglar breaking a window to get into a house, Indiana University researchers have discovered a previously unknown process by which pathogens enter a cell with physical force, breaching the body's immune defenses that prevent infection.

1 Dec 2023

Dissecting how co-transmission of interneurons helps in odor detection and discrimination

A longstanding hypothesis in neurobiology was that a single neuron releases a single type of neurotransmitter, a molecule used by neurons to communicate with one another.

28 Nov 2023

Researchers discover mechanism for memory storage in engram cells

What is the mechanism that allows our brains to incorporate new information about the world, and form memories? New work by a team of neuroscientists led by Dr Tomás Ryan from Trinity College Dublin shows that learning occurs through the continuous formation of new connectivity patterns between specific engram cells in different regions of the brain.

22 Nov 2023

Study reveals early role of SYNGAP1 gene in brain development

The gene SYNGAP1, the variants of which are top risk factors for Autism Spectrum Disorder (ASD), has previously unappreciated effects on the developing brain, according to a new study published in Nature Neuroscience.

9 Nov 2023

Inhibitory interneurons play a crucial role in fear memory expression and recall

Memory, a fundamental tool for our survival, is closely linked with how we encode, recall, and respond to external stimuli.

8 Nov 2023

DZNE neuroscientist awarded 1.5 million euros to investigate biophysical phenomena relevant to brain diseases

Dr. Dragomir Milovanovic, a neuroscientist at DZNE's Berlin site, has been awarded an European Research Council (ERC) "Starting Grant" worth 1.5 million euros to investigate biophysical phenomena relevant to brain diseases in a groundbreaking research project.

7 Nov 2023

TIMP2 protein identified as key player in brain plasticity and memory

Researchers explored the molecular and cellular processes regulated by tissue inhibitor of metalloproteinases-2 (TIMP2) in the extracellular matrix (ECM) of the adult brain hippocampus.

6 Nov 2023

Marijuana's psychoactive compound may alter brain wiring in adolescents

In a mouse study designed to explore the impact of marijuana's major psychoactive compound, THC, on teenage brains, Johns Hopkins Medicine researchers say they found changes to the structure of microglia, which are specialized brain immune cells, that may worsen a genetic predisposition to schizophrenia.

25 Oct 2023

Immune system proteins play role in early stages of Huntington's disease

Huntington's Disease is the most common neurodegenerative disorder controlled by a single gene and is characterized by motor and cognitive deficits and psychiatric symptoms.

12 Oct 2023

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Researchers examine the mechanisms responsible for the increased risk of neurocognitive impairment in HIV patients and explore potential treatments.

12 Oct 2023

Research explains the reason behind delay in therapeutic action of antidepressants

SSRI antidepressants normally take a few weeks before any showing mental health benefits, but how come it takes so long? Now a study from a group of clinicians and scientists provides the first human evidence that this is due to physical changes in the brain leading to greater brain plasticity developing over the first few weeks of SSRI intake.

9 Oct 2023

Harvard neuroscientist seeks to capture synapse-level connectome data from a mouse brain

The human brain is a tangled highway of wires emanating from nearly 100 billion neurons, all of which communicate across trillions of junctions called synapses. "Depressingly complex," Harvard neuroscientist Jeff Lichtman calls it.

9 Oct 2023

Unveiling the role of astrocyte-derived LCN2 in neurodegenerative disease progression

Researchers reviewed existing data on the neurodegenerative effects of astrocyte-derived lipocalin-2 (LCN-2).

4 Oct 2023

Protein p53 is linked directly to autism-like behavior, study shows

Researchers have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the protein-coding gene TP53 and neurodevelopmental and psychiatric disorders like autism spectrum disorder.

27 Sep 2023

Synapse News and Research

Patient-specific muscle models pave way for personalized neuromuscular therapies

What's my age again? Predicting disease and aging effects by studying organ aging using plasma proteomics data

IU researchers uncover novel mechanism of pathogen entry into cells

Dissecting how co-transmission of interneurons helps in odor detection and discrimination

Researchers discover mechanism for memory storage in engram cells

Study reveals early role of SYNGAP1 gene in brain development

Inhibitory interneurons play a crucial role in fear memory expression and recall

DZNE neuroscientist awarded 1.5 million euros to investigate biophysical phenomena relevant to brain diseases

TIMP2 protein identified as key player in brain plasticity and memory

Marijuana's psychoactive compound may alter brain wiring in adolescents

Immune system proteins play role in early stages of Huntington's disease

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Research explains the reason behind delay in therapeutic action of antidepressants

Harvard neuroscientist seeks to capture synapse-level connectome data from a mouse brain

Unveiling the role of astrocyte-derived LCN2 in neurodegenerative disease progression

Protein p53 is linked directly to autism-like behavior, study shows

Gaining new insights into neurological diseases by studying circular RNAs in brain cells

Study reveals how a causal factor in Angelman syndrome eliminates neural chat

Review finds correlation between milk oligosaccharides and infant brain development

Absence of two brain proteins may lead to compulsive repetitive behavior

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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