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Study reveals a promising therapeutic target for Alzheimer's disease

In a recent search for gene variants associated with Alzheimer's disease (AD), several affected families showed a mutation in an enzyme called protein kinase C-alpha (PKCα). Family members with this mutation had AD; those without the mutation did not.

28 Nov 2022

Utilizing marine sources to extract DHA to treat Alzheimer’s

The anti-neurodegenerative effects of docosahexaenoic acid (DHA) and DHA-rich phospholipids (DH-PL) derived from fisheries and aquaculture byproducts.

15 Nov 2022

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers reviewed research advancements showing the significant role both innate and adaptive immune systems play in the pathological course of Alzheimer’s disease.

10 Nov 2022

Scientists map neural pathways that lead to vomiting after eating contaminated food

A new study describes a system by which gut-brain pathways coordinate with brain circuits to initiate nausea and vomiting.

6 Nov 2022

Inflammation increases the expression of risk gene in first-episode schizophrenia patients

Schizophrenia patients have fewer connections between nerve cells. This is believed to be caused by genetic risk variants leading to an excessive elimination of nerve cell connections by the immune cells of the brain.

3 Nov 2022

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

A new study revealed that gut colonization by proteobacteria modulates cocaine neurobehavioral response in mice.

3 Nov 2022

Gut microbiota influences social behavior by stimulating microglial remodeling of brain circuits

To learn to socialize, zebrafish need to trust their gut. Gut microbes encourage specialized cells to prune back extra connections in brain circuits that control social behavior, new UO research in zebrafish shows.

1 Nov 2022

Researchers offer new insights into the neurobiological basis of autism spectrum disorders

Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth's Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the neurobiological basis of autism spectrum disorders (ASD) and pointing to possible treatments.

1 Nov 2022

Study provides insight into how sleep and wakefulness regulate inhibitory synapses

Using a mouse model, researchers have discovered a new daily rhythm in a type of synapse that dampens brain activity.

1 Nov 2022

Structure of the irregular neuronal connection strengths contains a hidden order, study finds

In the brain, our perception arises from a complex interplay of neurons that are connected via synapses. But the number and strength of connections between certain types of neurons can vary.

14 Oct 2022

Star-shaped brain cells can "turn off" neurons involved in heroin relapse

Neuroscientists from the Medical University of South Carolina report in Science Advances that star-shaped brain cells known as astrocytes can "turn off" neurons involved in relapse to heroin.

5 Oct 2022

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Researchers explored the effect of SARS-CoV-2 exposure on the brain.

20 Sep 2022

Study reveals pathological mechanisms of synaptic dysfunction in patients with Huntington's disease

Huntington's disease (HD) is a hereditary brain disease caused by a mutation in the huntingtin gene. HD is a neurodegenerative disease without a cure that, after the onset of the disease at around 40 years of age, causes changes in personality and symptoms of dementia along with uncontrollable convulsive movements, ultimately leading to death.

19 Sep 2022

Mechanical forces generated by T cells influence the destruction of cancer cells

As a part of our immune defenses, cytotoxic T cells – or killer T cells – seek out and destroy cells that are infected or cancerous. This process is essential for the body's defense against diseases.

15 Sep 2022

New kind of synapse discovered in neurons’ tiny hairs

Scientists at HHMI's Janelia Research Campus have discovered a new kind of synapse in the tiny hairs on the surface of neurons.

1 Sep 2022

Alzheimer's disease disrupts visual memory by degrading cross-hemispheric cells

A new MIT study finds that Alzheimer's disease disrupts at least one form of visual memory by degrading a newly identified circuit that connects the vision processing centers of each brain hemisphere.

19 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

Most drugs developed to treat Alzheimer's disease have for years been ineffective in clinical trials. Researchers from Indiana University School of Medicine recently evaluated the efficacy of a failed clinical trial drug using their rigorous pipeline.

25 Jul 2022

LMU cell biologists show how interactions between RNA-binding proteins affect synaptic plasticity in neurons

LMU scientists demonstrate that interactions between RNA-binding proteins affect translation and consequently the complexity of neurons.

4 Jul 2022

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

A new study that analyzed protein levels in 2,002 primary tumors from 14 tissue-based cancer types identified 11 distinct molecular subtypes, providing systematic knowledge that greatly expands a searchable online database that has become a go-to platform for cancer data analysis by users worldwide.

10 Jun 2022

Synapse News and Research

Study reveals a promising therapeutic target for Alzheimer's disease

Utilizing marine sources to extract DHA to treat Alzheimer’s

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Scientists map neural pathways that lead to vomiting after eating contaminated food

Inflammation increases the expression of risk gene in first-episode schizophrenia patients

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

Gut microbiota influences social behavior by stimulating microglial remodeling of brain circuits

Researchers offer new insights into the neurobiological basis of autism spectrum disorders

Study provides insight into how sleep and wakefulness regulate inhibitory synapses

Structure of the irregular neuronal connection strengths contains a hidden order, study finds

Star-shaped brain cells can "turn off" neurons involved in heroin relapse

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Study reveals pathological mechanisms of synaptic dysfunction in patients with Huntington's disease

Mechanical forces generated by T cells influence the destruction of cancer cells

New kind of synapse discovered in neurons’ tiny hairs

Alzheimer's disease disrupts visual memory by degrading cross-hemispheric cells

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

LMU cell biologists show how interactions between RNA-binding proteins affect synaptic plasticity in neurons

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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