TIRF Microscopy News and Research

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TIRF is a microscopy technique that is used to image fluorescent molecules, such as green fluorescent protein (GFP) and fluorochromes, in liquids that are adjacent to a solid with a high refractive index.

A novel multiplexed diagnostic approach for COVID-19

Researchers developed a platform for detecting the virus directly from a patient's sample as well as the immune response through antibodies such as IgG and IgM.

31 May 2021

Biologists observe how microtubules branch in new directions in animal cells

Cell biologist Thomas Maresca and senior research fellow Vikash Verma at the University of Massachusetts Amherst say they have, for the first time, directly observed and recorded in animal cells a pathway called branching microtubule nucleation, a mechanism in cell division that had been imaged in cellular extracts and plant cells but not directly observed in animal cells.

16 Sep 2019

X Line Objective Lenses Break Optical Barriers with Simultaneously Improved Image Flatness, Chromatic Aberration Correction and Numerical Aperture

Designed with new manufacturing technology that creates lenses with shapes that are difficult to fabricate using other methods, Olympus’ new X Line series objectives and the UPLAPO-HR objectives for super resolution and TIRF microscopy break optical barriers to deliver outstanding image quality.

From Evident Corporation 21 Jun 2019

Olympus launches next-generation X Line objectives for clinical, research applications

Olympus delivers a breakthrough to life science microscopy with the launch of its next-generation X Line objectives.

From Evident Corporation 4 Jun 2019

FDA takes new steps to address opioid crisis by approving Opioid Analgesic Risk Evaluation and Mitigation Strategy

Today, the U.S. Food and Drug Administration took new steps as part of its broader efforts to address the opioid crisis by approving the final Opioid Analgesic Risk Evaluation and Mitigation Strategy.

19 Sep 2018

Economical Fluorescence Adapter for Stereo Microscopes

An interview with Charles Mazel, President of NIGHTSEA, conducted by Barbara Foster, The Microscopy & Imaging Place, Inc.

From NIGHTSEA 25 Jan 2018

Leica introduces new DMi8 S solution for fast, versatile microscopic imaging of living cells

Leica introduces the DMi8 S, a new complete solution designed to give researchers the ultimate tool for fast, versatile microscopic imaging of living cells allowing scientists to find, observe and interact with living cells like never before.

From Leica Microsystems GmbH 25 May 2017

Liverpool researchers use JPK's NanoWizard AFM system to study biological membrane structures, protein dynamics

JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of their NanoWizard ULTRA Speed AFM system at the University of Liverpool in the group of Dr Luning Liu of the Institute of Integrative Biology to study biological membrane structures and protein dynamics.

From Bruker BioAFM 23 Mar 2016

Key sequence in killer cells captured by Andor revolution microscope

Although much is known of the immune response to antigen-presenting cells, until now the way the body's own killer cells establish an immunological synapse to destroy those target cells has remained unclear. Now, an international research team led by Professor Gillian Griffiths of Cambridge University has resolved the key sequence of events using high-resolution 4D imaging.

15 Sep 2015

High speed cellFRAP imaging platform for dynamic in-vivo processes

Olympus introduces a flexible and accurate cellFRAP imaging platform specifically for the acquisition, monitoring and analysis of dynamic in-vivo processes by photomanipulation techniques. The easy-to-use platform delivers excellent optical performance and µs-precise control.

1 Sep 2015

BDSI announces FDA approval of sNDA for new formulation of ONSOLIS (fentanyl buccal soluble film) CII

BioDelivery Sciences International, Inc. announced the approval by the U.S. Food and Drug Administration of a Supplemental New Drug Application (sNDA) for a new formulation of ONSOLIS (fentanyl buccal soluble film) CII for the management of breakthrough pain in patients with cancer who are opioid tolerant.

13 Aug 2015

Next generation quantitative live-cell microscope released by Bruker

Bruker today announced the release of the Opterra II™ Multipoint Scanning Confocal Microscope, which represents the next generation of quantitative live-cell microscopes.

From Bruker 11 Aug 2015

Accessible TIRF solutions for every application

Olympus expands its range of cellTIRF illuminators and accessories with the new economic one-line illuminator (cellTIRF-1L), which complements the high-end, 4- and 2-line (cellTIRF MITICO 4L/2L) illuminators.

From Evident Corporation 10 Feb 2015

New study shows mechanism behind tubulin transport in cilia

Defective cilia can lead to a host of diseases and conditions in the human body--from rare, inherited bone malformations to blindness, male infertility, kidney disease and obesity. Scientists knew that somehow these tiny cell organelles become deformed and cause these diseases because of a problem related to their assembly, which requires the translocation of vast quantities of the vital cell protein tubulin.

28 Jan 2015

Linden Care announces new national contract under Comprehensive Hub Solutions Program

Linden Care LLC, a leading provider of comprehensive specialty pharmacy solutions to the pain management industry and a portfolio company of BelHealth Investment Partners, announced a new national contract under its Comprehensive Hub Solutions Program (the "Program").

11 Nov 2014

Live cell imaging solution launched by QImaging

QImaging™ today launched a new, all-in-one camera package that supports demanding live cell fluorescence imaging requirements. The Live Cell Imaging Package provides researchers with the sensitivity of EMCCD and the versatility of sCMOS camera technologies by combining QImaging’s Rolera™ Thunder EMCCD and optiMOS™ sCMOScameras. Now, researchers can address their unique imaging needs for a broader, more diverse set of scientific applications.

21 Aug 2014

ProStrakan announces FDA approval for Transmucosal Immediate Release Fentanyl REMS Access program

ProStrakan, Inc., a subsidiary of Kyowa Hakko Kirin Co. Ltd., and an international specialty pharmaceutical company, today announces that the U.S. Food and Drug Administration has approved the TIRF (Transmucosal Immediate Release Fentanyl) REMS Access program.

31 Dec 2011

Single shared REMS for TIRF products receives FDA approval

The U.S. Food and Drug Administration today approved a single shared Risk Evaluation and Mitigation Strategy (REMS) for the transmucosal immediate-release fentanyl (TIRF) products. This new shared system will replace the individual REMS and allow prescribers and pharmacies to enroll into just one system, easing the burden on the health care system.

30 Dec 2011

NCRR awards 450 Recovery Act instrumentation grants to NIH-funded scientists

Leading-edge, shared technologies are an important component of advancing research to improve health. Specialized instruments such as high-powered electron microscopes, high-resolution mass spectrometers and supercomputers that rapidly process vast amounts of data can enable breakthrough discoveries in preventions, treatments and cures for diseases.

22 Oct 2010

Study offers new possibilities for breast and other cancer therapies

Conventional biological wisdom holds that living cells interact with their environment through an elaborate network of chemical signals. As a result many therapies for the treatment of cancer and other diseases in which cell behavior goes awry focus on drugs that block or disrupt harmful chemical signals.

16 Mar 2010