TNF Blockers News and Research

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Omega-3 fatty acids ineffective for managing Crohn's disease

An international study led by Dr. Brian Feagan of Robarts Research Institute at The University of Western Ontario in London, Canada has found that omega-3 fatty acids are ineffective for managing Crohn's disease.

9 Apr 2008

Tart cherries cut heart/diabetes risk factors

Tart cherries - frequently sold dried, frozen or in juice - may have more than just good taste and bright red color going for them, according to new animal research from the University of Michigan Cardiovascular Center.

7 Apr 2008

Discovery of new genetic links to psoriasis

In the first comprehensive study of the genetic basis of psoriasis, researchers at Washington University School of Medicine in St. Louis have discovered seven new sites of common DNA variation that increase the risk of the troublesome skin condition.

4 Apr 2008

Discovery of new mechanism involved in inflammatory diseases

Investigators at Hospital for Special Surgery have identified a new mechanism involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis.

17 Mar 2008

Researchers find treatment for familial cold autoinflammatory syndrome

Dalhousie Medical School dermatologist Dr. Barrie Ross and his colleagues have successfully ended a 20-year quest to find a treatment for Familial Cold Autoinflammatory Syndrome (FCAS).

12 Mar 2008

Once-a-week arthritis pill significantly reduces the risk of heart attacks

A once-a-week pill to treat rheumatoid arthritis significantly reduces the risk of heart attack and stroke for people with the painful joint condition.

10 Mar 2008

Watery pools in bone marrow key to psoriatic arthritic damage

Researchers have learned more about how a leading drug prevents certain types of arthritis from eating away at bone, according to a study published in the March edition of the Annals of the Rheumatic Diseases.

4 Mar 2008

Effect of tumor necrosis factor a inhibitors on heart failure risk in rheumatoid arthritis

A chronic autoimmune disease, rheumatoid arthritis (RA) is characterized by persistent inflammation of the synovial membrane and progressive joint destruction.

28 Feb 2008

Abbott receives approval for HUMIRA (Adalimumab) for polyarticular juvenile idiopathic arthritis

Abbott has announced that it has received U.S. Food and Drug Administration (FDA) approval to market HUMIRA (adalimumab) as a treatment to reduce signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in patients four years of age and older.

26 Feb 2008

Enbrel shown to significantly reduced levels of C-reactive protein

Amgen and Wyeth Pharmaceuticals, a division of Wyeth have announced findings from a retrospective analysis, which demonstrated that ENBREL reduced C-reactive protein (CRP), a marker of inflammation, in patients with moderate to severe plaque psoriasis following 12 weeks of treatment. Median reduction in CRP levels was 10 times greater in the ENBREL treated group compared to the placebo treated group.

5 Feb 2008

How anti-TNF compounds work

Powerful drugs used to treat patients with rheumatoid arthritis have a profound, previously unrecognized effect on the immune system, breaking up molecular "training camps" for rogue cells that play an increasingly recognized role in autoimmune diseases like rheumatoid arthritis and lupus.

21 Jan 2008

Scientists focus on Epstein-Barr virus

Epstein-Barr virus (EBV) is a human-pathogenic virus which belongs to the herpes virus family.

18 Jan 2008

New drug lets kids feel good in their skin

Maria Anichini, a 20-year-old junior at Columbia College, zipped up a fetching black lace cocktail dress with spaghetti straps to go out with friends the other night.

17 Jan 2008

Etanercept drug reverses early symptoms of Alzheimer's in 10 minutes

Scientists in the U.S. say a drug which can reverse some of the early symptoms of Alzheimer's disease takes effect within 10 minutes.

14 Jan 2008

New study highlights importance soluble proteins, called cytokines, in Alzheimer's

An extraordinary new scientific study, which for the first time documents marked improvement in Alzheimer's disease within minutes of administration of a therapeutic molecule, has just been published in the Journal of Neuroinflammation .

10 Jan 2008

sLRP1-alpha provides relief from neuropathic pain

Injury to peripheral nerves (the causes of which include shingles, HIV-AIDS, toxins, alcoholism, repetitive motion disorders, surgery, and cancer) causes neuropathic pain, which differs from ordinary pain and is usually perceived as a steady burning, pins and needles, electric shock sensations, and/or tickling.

4 Dec 2007

Experimental gene therapy trial for arthritis allowed to resume

Trials in the U.S. of a controversial and experimental gene therapy have been given the green light to resume following the tragic death of a volunteer in July.

27 Nov 2007

New insight into ulcerative colitis

Social, environmental and dietary changes are associated with the changes of disease spectrum in a country. Ulcerative colitis has become a commonly seen disease in China, probably due to extensive consumption of Western foods in recent years.

14 Nov 2007

Infliximab scheduled treatment has proven to be an effective strategy in IBD patients

Crohn's disease (CD) and ulcerative colitis (UC) are chronic-relapsing diseases, the clinical courses of which are characterized by periods of remission and periods of acute flare up, determining clinical symptoms which have a strong impact on the quality of life for patients.

25 Oct 2007

Increased intestinal permeability by exogenous sphingomyelinase

Many signaling molecules involved in the pathogenesis of IBD, such as TNF or IFN, infections with bacteria or viruses and ionizing radiation, may cause an alteration of the lipid composition in the cell membrane by activation of sphingomyelinases (SMases).

24 Oct 2007