Tamoxifen News and Research

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Tamoxifen is a drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen. Also called tamoxifen citrate.

Study offers potential new strategy for use of retinoids against some breast cancers

Estrogen-positive breast cancers are often treated with anti-estrogen therapies. But about half of these cancers contain a subpopulation of cells marked by the protein cytokeratin 5 (CK5), which resists treatment -- and breast cancers with higher CK5 expression have poorer prognosis.

26 Jul 2017

Perceived side effects to Tamoxifen making many quit breast cancer drug

According to a new study by a team of researchers led by the Queen Mary University of London, women who have been prescribed Tamoxifen as a cancer preventive are failing to take the medicine owing to perceived side effects from the drug. Some of the symptoms that they report as distressing are caused naturally by the disease condition rather than the drug explain researchers.

29 Jun 2017

Breast cancer drug offers protection against obesity-related metabolic disorders

Tamoxifen, a selective estrogen receptor modulator, is the gold standard for endocrine treatment of estrogen-receptor positive breast cancer.

11 May 2017

Scientists identify new gene that drives drug resistance in breast cancer

SCIENTISTS in Salford, UK, have identified a gene which is 'revving the engine of cancer' against the world's most common breast cancer drug.

4 Apr 2017

SLU researchers aim to tackle diabetes and obesity by capturing benefits of exercise in pill form

With a series of new grants, Saint Louis University researchers will tackle the twin epidemics of diabetes and obesity by tapping into the potential of two nuclear receptors that control muscle metabolism.

24 Mar 2017

Scientists identify molecules that may be key to drug resistance in estrogen-driven breast cancers

Three-quarters of all breast cancer tumors are driven by the hormone estrogen. These tumors are frequently treated with drugs to suppress estrogen receptor activity, but unfortunately, at least half of patients do not respond to these treatments, leaving them with drug-resistant tumors and few options.

20 Mar 2017

Shorter radiation treatment for breast cancer patients could reduce health care spending

More than half of older women with early stage breast cancer received more radiation therapy than what might be medically necessary, adding additional treatment and health care costs, according to a study led by Duke Cancer Institute researchers.

15 Mar 2017

Isoflavone consumption linked to decrease in mortality for some breast cancer patients

An epidemiological analysis of data from more than 6,000 American and Canadian women with breast cancer finds that post-diagnosis consumption of foods containing isoflavones—estrogen-like compounds primarily found in soy food—is associated with a 21 percent decrease in all-cause mortality.

6 Mar 2017

Dietary soy products could be safe, beneficial for women diagnosed with breast cancer

New research indicates that dietary soy products are safe and even beneficial for women diagnosed with breast cancer. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may help resolve controversies over soy's potential link to breast cancer outcomes.

6 Mar 2017

Study finds under and misuse of adjuvant endocrine therapy for breast cancer patients

A nationwide cancer registry of almost one million patients treated for hormone-sensitive breast cancer shows that one out of six women who should have received post-surgical treatment known as adjuvant endocrine therapy (AET) did not get this recommended component of care.

3 Feb 2017

Researchers reveal how soy consumption impacts common breast cancer treatment

Georgetown Lombardi Comprehensive Cancer Center researchers have used animal models to reveal new information about the impact - positive and negative - that soy consumption could have on a common breast cancer treatment.

1 Feb 2017

Delays in availability of new treatments and incomprehensible price rises disadvantage cancer patients

Cancer patients are living longer and in many cases the disease is becoming chronic rather than acute. Access to drugs that help extend life and improve quality of life, and fair prices for those drugs are therefore essential for more and more people.

28 Jan 2017

TSRI researchers develop new approach to find how environmental estrogens impact public health

Breast cancer researchers from the Florida campus of The Scripps Research Institute have developed a novel approach for identifying how chemicals in the environment—called environmental estrogens—can produce infertility, abnormal reproductive development, including “precocious puberty,” and promote breast cancer.

3 Jan 2017

TSRI scientists develop new approach for understanding diverse effects of endocrine-disruptors

Breast cancer researchers from the Florida campus of The Scripps Research Institute (TSRI) have developed a novel approach for identifying how chemicals in the environment--called environmental estrogens--can produce infertility, abnormal reproductive development, including "precocious puberty," and promote breast cancer.

30 Dec 2016

Aromatase inhibitors show advantages over tamoxifen in early-stage breast cancer

The German Institute for Quality and Efficiency in Health Care (IQWiG) investigated whether and what advantages drugs from the drug class of aromatase inhibitors offer compared with other breast cancer treatments or with each other.

30 Dec 2016

Research findings could offer novel approach for cancer prevention in women with BRCA1 mutations

Women with inherited mutations in the BRCA1 or BRCA2 genes are at substantially higher risk of breast cancer. For these women, effective prevention strategies are their best hope to reduce their breast cancer risk.

16 Dec 2016

Multifunctional RNA nanoparticles could overcome treatment resistance in breast cancer, study shows

Researchers at the University of Cincinnati College of Medicine have been able to generate multifunctional RNA nanoparticles that could overcome treatment resistance in breast cancer, potentially making existing treatments more effective in these patients.

15 Dec 2016

One fifth of breast cancer patients do not complete their prescribed endocrine therapy

Around 20% of breast cancer patients do not complete prescribed endocrine therapy, researchers report at the ESMO Asia 2016 Congress in Singapore.1 The study in over 5,500 women found that younger patients and those who had taken hormone replacement therapy (HRT) were less likely to adhere to their medicine.

14 Dec 2016

Symptoms from other causes may be mistaken for side effects of breast cancer drug

Women taking tamoxifen to prevent breast cancer were less likely to continue taking the drug if they suffered nausea and vomiting, according to new data presented at the San Antonio Breast Cancer Symposium today (Friday).

9 Dec 2016

Controversial hormone could fight against recurring breast cancers

An international team of researchers involving the University of Adelaide is tackling the controversy over what some scientists consider to be a "harmful" hormone, arguing that it could be a game changer in the fight against recurring breast cancers that are resistant to standard treatments.