Therapeutics News and Research

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Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells

Researchers from Weill Cornell Medicine have used a cutting-edge model system to uncover the mechanism by which SARS-CoV-2, the virus that causes COVID-19, induces new cases of diabetes, and worsens complications in people who already have it.

13 Sep 2024

Breakthrough study sheds light on mechanisms behind the spread of gastric cancer to the peritoneum

Gastric cancer remains a formidable adversary, ranking as the fifth most common cancer and the third-leading cause of cancer-related deaths worldwide, with over 1,000,000 new cases and close to 770,000 deaths each year.

13 Sep 2024

New mechanism aims to ensure equitable distribution of mpox vaccines and treatments

In coordination with Member States, the World Health Organization (WHO) and partners have established an access and allocation mechanism for mpox medical countermeasures including vaccines, treatments and diagnostic tests.

13 Sep 2024

ISM2196: A promising AI-developed WRN inhibitor for advanced metastatic cancers

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced the nomination of ISM2196, an AI-driven, potential best-in-class small molecule WRN inhibitor targeting advanced metastatic microsatellite instability (MSI) cancers guided by synthetic lethality strategy.

13 Sep 2024

Significant global cardiovascular risk linked to high lipoprotein(a) levels

Review in The Lancet finds that one in five globally are at risk of contracting cardiovascular diseases, because they carry a genetic risk of high levels of a specific lipoprotein, which can be tested for and possibly treated.

12 Sep 2024

Early Phase I data shows promise for mRNA cancer immunotherapy in advanced solid cancers

Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.

12 Sep 2024

High-dose amphetamine use linked to increased risk of psychosis or mania

Prescribing rates for stimulants that treat attention-deficit/hyperactivity disorder (ADHD) have increased significantly over the past decade, with some of the largest increases reported during the COVID-19 pandemic.

12 Sep 2024

Study links protein increases to cognitive improvement in Alzheimer's

A study published in the journal Brain shows that increases in protein levels with new Alzheimer's drugs can explain the slowing of cognitive impairment at least as well as the reduction in amyloid plaques.

11 Sep 2024

MSK researchers identify a new, rare type of small cell lung cancer

A team of doctors and researchers at Memorial Sloan Kettering Cancer Center (MSK) have identified a new, rare type of small cell lung cancer that primarily affects younger people who have never smoked.

11 Sep 2024

Ropirio Therapeutics secures exclusive license for novel lymphatic system activators

The Wyss Institute at Harvard University announced today that Ropirio Therapeutics, Inc. (Ropirio) has secured a worldwide, exclusive license from Harvard's Office of Technology Development (OTD) and Boston University (BU)'s Technology Development office for novel molecules that activate the lymphatic system - a first in the pharma industry.

11 Sep 2024

Study reveals shared and unique molecular markers across multiple forms of dementia

Researchers have for the first time identified degeneration-associated "molecular markers" – observable changes in cells and their gene-regulating networks – that are shared by several forms of dementia that affect different regions of the brain.

11 Sep 2024

New acoustic tweezers isolate viruses from saliva with high precision

Developing antiviral therapeutics and vaccines requires close study of the viruses that cause disease. But how can these small germs be isolated from complex biological samples like saliva?

11 Sep 2024

Study unveils potential treatment for chronic brain damage following traumatic injury

Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI.

11 Sep 2024

A promising new therapeutic target for MASLD identified

Using a novel stem cell platform, a team of the Medical University of South Carolina researchers has identified a pathway that could be targeted by drugs to reduce fat accumulation in patients with a common form of fatty liver disease known as metabolic dysfunction-associated steatotic liver disease, or MASLD.

11 Sep 2024

Air pollution spikes drive unnecessary antibiotic use, fueling resistance

Short-term exposure to air pollution significantly increases antimicrobial use for acute respiratory symptoms, highlighting a potential contributor to antibiotic resistance.

10 Sep 2024

New target identified for potential ALS therapy

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects motor neurons.

10 Sep 2024

New normative neuroimaging library sets standard for brain injury research

With recent advances in neuroimaging, moving from qualitative to quantitative outputs, an understanding is needed of what normal data look like to be able to apply these advances to diagnosis and outcomes prediction in traumatic brain injury (TBI).

10 Sep 2024

Age-related fibroblast changes in males drive aggressive melanoma

Age-related changes in the fibroblasts, cells that create the skin's structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.

6 Sep 2024

Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models

A study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol (CBD), a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome.

6 Sep 2024