Therapeutics News and Research

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New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

FDA approves Remodulin for the treatment of pulmonary arterial hypertension

United Therapeutics Corporation announced today that the U.S. Food and Drug Administration (FDA) has issued an approval letter for the intravenous use of Remodulin based on data establishing its bioequivalence with the previously approved subcutaneous administration of Remodulin.

24 Nov 2004

Discovery of a new cancer gene, which, when damaged, may promote prostate cancer

Together with an international research team, researchers from VTT Technical Research Centre of Finland have developed an effective method for the screening and identification of genes that under normal conditions suppress cancer growth.

24 Nov 2004

Survey shows need for conservative, drug-free options

A new survey showing that nearly half of all Americans are concerned about the safety of the medical care they receive should send a strong signal to the health and insurance industries that safer non-drug, non-surgical treatments should be considered whenever possible, according to the American Chiropractic Association (ACA).

20 Nov 2004

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

This structure should prove extremely useful in the rational design of small molecule inhibitors of PKCÈ, which has been implicated in T-cell mediated disease processes including inflammation and autoimmunity.

19 Nov 2004

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Scientists have found that overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) blocks the formation of new blood vessels and thus reduces tumor growth. Therapeutics based on this finding may potentially lead to new cancer treatments.

19 Nov 2004

Capsules may be effective in treating bipolar disorder

University of North Carolina at Chapel Hill researchers have announced study results finding that a formulation of three-beaded extended-release carbamazepine capsules (ERC-CBZ) was effective, safe and tolerable in the treatment of bipolar I disorder

19 Nov 2004

Family experience guides Alzheimer’s research

After watching his father struggle with and ultimately succumb to Alzheimer’s disease, ASU professor Michael Sierks shifted his research focus from starch hydrolyzing to neurodegenerative diseases.

18 Nov 2004

New findings have implications for chronic use of COX-2 Inhibitors in pre-menopausal women

Heart disease is less pronounced in women than in men as humans age, but this difference narrows after menopause. Some studies have shown that estrogen slows heart disease in mouse models, but the mechanism is largely unknown.

18 Nov 2004

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc., has been allowed a patent by the Canadian Patent Office entitled "Antitumor Antisense Sequences Directed Against R1 and R2 Components of Ribonucleotide Reductase."

10 Nov 2004

Nanogen announces clinical diagnostic to simultaneously detect multiple respiratory viruses

Nanogen announced today that it is developing new analyte specific reagents (ASRs) for clinical reference laboratories to develop and validate a single test to detect six of the most common respiratory viruses.

10 Nov 2004

Bretylium tosylate has unique benefits for patients with acute myocardial infarction

An "old" drug has unique benefits for patients with acute myocardial infarction (AMI; commonly known as heart attack), a finding that may contribute to a new understanding of how heart attacks develop, according to an article in the September/October American Journal of Therapeutics.

10 Nov 2004

New studies demonstrate efficacy of novel Lipoxin analog in laboratory models of Crohn's disease

Berlex announced today that new laboratory results demonstrate that its modified version of the naturally occurring lipoxin molecule exerts potent anti-inflammatory and immunomodulatory effects in Crohn's disease in vivo models and may provide a promising new oral treatment.

9 Nov 2004

Australian trial set to transform nursing home care

Medications trolleys in nursing homes may soon become mobile medical centres. The University of New South Wales has won a $300,000 grant to develop and trial a new point-of-care system that will allow nursing staff to manage medications, check patients’ clinical signs and streamline administration and clinical interaction with patients’ GPs.

8 Nov 2004

U.S. Patent for generating genetically altered antibody producing cell lines

Morphotek announced today the issuance of United States Patent 6,808,894 covering the generation of genetically enhanced antibody producer cell lines.

8 Nov 2004

The first test in humans of a bioartificial kidney

The first test in humans of a bioartificial kidney offers hope of the device's potential to save the lives of people with acute renal failure, researchers at the University of Michigan Health System report.

4 Nov 2004

Gene silencing may provide hope for leukemia sufferers

Ever since the approval of Gleevec in 2001, a cancer-cell-specific drug used to treat chronic myelogenous leukemia (CML), the field of cancer therapeutics has been rushing full speed into the era of so-called "targeted" medicines.

1 Nov 2004

Micro-array technology is revolutionising current drug development

Gene expression micro-array technology is benefiting all phases of the discovery, development and subsequent use of new cancer therapeutics

29 Oct 2004

National Cancer Institute symposium exploring the application of nanotechnology in the diagnosis, treatment and prevention of cancer

The Case Comprehensive Cancer Center, which includes The Cleveland Clinic Taussig Cancer Center and the Ireland Cancer Center at University Hospitals of Cleveland, will sponsor a National Cancer Institute symposium exploring the application of nanotechnology in the diagnosis, treatment and prevention of cancer.

25 Oct 2004

Potential new protein marker for prognosis of breast and ovarian cancer

The researchers matched tumor samples to outcomes in about 100 patients diagnosed with either breast or ovarian cancer and found that a low level of Rab25 protein on a patient's cancer sample was associated with a better clinical outcome in both cancer types.

24 Oct 2004

Therapeutics News and Research

New research may lead to treatments for atherosclerosis

FDA approves Remodulin for the treatment of pulmonary arterial hypertension

Discovery of a new cancer gene, which, when damaged, may promote prostate cancer

Survey shows need for conservative, drug-free options

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Capsules may be effective in treating bipolar disorder

Family experience guides Alzheimer’s research

New findings have implications for chronic use of COX-2 Inhibitors in pre-menopausal women

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Nanogen announces clinical diagnostic to simultaneously detect multiple respiratory viruses

Bretylium tosylate has unique benefits for patients with acute myocardial infarction

New studies demonstrate efficacy of novel Lipoxin analog in laboratory models of Crohn's disease

Australian trial set to transform nursing home care

U.S. Patent for generating genetically altered antibody producing cell lines

The first test in humans of a bioartificial kidney

Gene silencing may provide hope for leukemia sufferers

Micro-array technology is revolutionising current drug development

National Cancer Institute symposium exploring the application of nanotechnology in the diagnosis, treatment and prevention of cancer

Potential new protein marker for prognosis of breast and ovarian cancer

Hasret Altan-Martin

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