Therapeutics News and Research

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RNAi therapeutic successful for treatment of SARS respiratory virus in Rhesus Macaque

Intradigm Corporation announced today its collaboration with Chinese academic and biotech groups has achieved clear evidence of prophylactic and therapeutic effects of siRNA (small interfering RNA) agents in Rhesus monkey to treat SARS coronavirus (SCV) respiratory infection.

12 Sep 2005

Inhaled-insulin drug Exubera - monitoring programme to be launched by Pfizer

Drug company Pfizer says it is all set to launch a patient-monitoring scheme in order to assess the safety of its novel inhaled-insulin drug Exubera, if the product is approved for use.

10 Sep 2005

Strokes and heart attacks can be prevented in people with high blood pressure

Most strokes and heart attacks in people with high blood pressure can be abolished by simply combining effective, modern blood pressure lowering drugs with treatment to reduce cholesterol.

6 Sep 2005

Domantis successful in patent opposition

Domantis Limited, the human Domain Antibody Therapeutics company, has successfully opposed European patent number EP0656946, leading to a major amendment of the main claim in the patent and a significant narrowing of the scope of 34 of the 41 other claims.

1 Sep 2005

Anti-cancer antibodies produced in chickens

A team of researchers have produced the first fully functional, human sequence monoclonal antibodies (mAbs) in chickens.

29 Aug 2005

First clinical trial of a biologic nanoparticle designed to give back to cancer patients the tumor-busting gene they have lost

The phase I clinical study will enroll 20 patients with advanced solid cancers (including most common tumor types), and is the culmination of more than a decade of work by a team of researchers led by Professor Esther H. Chang, Ph.D. at the Lombardi Comprehensive Cancer Center.

25 Aug 2005

Lorus identifies novel class of lead drug candidates from small molecule anticancer program

Lorus Therapeutics has announced the continued success in the development of its small molecule anticancer program with the selection of a sub-class of lead molecules from the Company's small molecule program.

24 Aug 2005

Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

EntreMed a clinical-stage pharmaceutical company developing therapeutics primarily for the treatment of cancer and inflammatory diseases, has announced the presentation of positive preclinical results for its lead compound, 2-methoxyestradiol (2ME2), in models of rheumatoid arthritis.

24 Aug 2005

FDA Approves Aceon to reduce risk of cardiovascular mortality in patients with stable coronary artery disease

Solvay Pharmaceuticals and CV Therapeutics have announced that the U.S. Food and Drug Administration (FDA) has approved Aceon (perindopril erbumine) Tablets for the treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or non-fatal myocardial infarction (MI).

24 Aug 2005

Discovery of a potential oncogene in ovarian cancer

Researchers at The University of Texas M. D. Anderson Cancer Center report they have discovered a potential oncogene in ovarian cancer, which is the leading cause of gynecological cancer death in U.S. women.

22 Aug 2005

Combined gene therapy eliminates glioblastoma multiforme in lab studies

Despite aggressive treatment, glioblastoma multiforme (GBM) - the most common and deadly of brain cancers - usually claims the lives of its victims within six to 12 months of diagnosis. Because GBM is so aggressive, the disease has been the target of a number of laboratory and clinical studies investigating the effectiveness of gene therapy to deliver novel therapies to the brain.

15 Aug 2005

Defect in the gene that makes YAP might contribute to cancer

Johns Hopkins scientists have identified a protein in fruit flies whose counterpart product in humans may help cause cancer.

11 Aug 2005

Introgen announces additional broad patent in China

Introgen Therapeutics has announced that a patent with broad claims directed to combination therapy with the p53 gene and conventional chemotherapy or radiation was issued in China.

11 Aug 2005

Researchers discover that tumors secrete fatty acids which inhibit the cytotoxic T lymphocytes' ability to kill tumor cells

Researchers have discovered that tumors release fatty acids that interfere with the cells that are trying to kill them. Consequently, strategies that reduce the amount of fatty acids surrounding the tumors may give a boost to anti-cancer therapeutics.

11 Aug 2005

Researchers characterize the proteome of the human cornea

In doing so, they have identified 141 distinct proteins, 99 of which had not been previously recognized in mammalian corneas. The details of their findings appear in the August/September issue of Molecular and Cellular Proteomics, an American Society for Biochemistry and Molecular Biology journal.

1 Aug 2005

Inhibitors of cellular enzymes could be developed for SARS treatment

Researchers from the University of Pennsylvania School of Medicine have found that inhibitors of an enzyme called cathepsin L prevent the SARS (severe acute respiratory syndrome) virus from entering target cells. SARS is caused by an emergent coronavirus. There is no effective treatment at this time.

1 Aug 2005

Participants in the gene therapy market discover new ways to improve clinical efficiency and generate revenue

The gene therapy market has had limited success with products during the clinical development process. Due to toxicological complications and poor therapy efficacy, healthcare authorities have suspended several gene therapy trials worldwide.

28 Jul 2005

$4.7million grant for research on neuroblastoma

Significant funding from Australia's National Health and Medical Research Council will enable researchers at Children’s Cancer Institute Australia (CCIA) for Medical Research to make progress on the treatment of one the most aggressive, drug-resistant childhood cancers - neuroblastoma - over the next five years.

28 Jul 2005

Acetaminophen, when taken as directed, is safe for patients with liver disease

Contrary to common perception, clinical data demonstrate that acetaminophen is an appropriate pain relief choice for patients with chronic liver disease. According to a systematic literature review of the data, which is published in the current issue of the American Journal of Therapeutics, there is no evidence that acetaminophen at therapeutic doses aggravates liver disease.

26 Jul 2005

Government in Ontario will pay for three new cancer drugs

Canadian Health Minister George Smitherman has announced that the government will add three new and expensive cancer-fighting drugs to the list of medications it funds.

25 Jul 2005

Therapeutics News and Research

RNAi therapeutic successful for treatment of SARS respiratory virus in Rhesus Macaque

Inhaled-insulin drug Exubera - monitoring programme to be launched by Pfizer

Strokes and heart attacks can be prevented in people with high blood pressure

Domantis successful in patent opposition

Anti-cancer antibodies produced in chickens

First clinical trial of a biologic nanoparticle designed to give back to cancer patients the tumor-busting gene they have lost

Lorus identifies novel class of lead drug candidates from small molecule anticancer program

Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

FDA Approves Aceon to reduce risk of cardiovascular mortality in patients with stable coronary artery disease

Discovery of a potential oncogene in ovarian cancer

Combined gene therapy eliminates glioblastoma multiforme in lab studies

Defect in the gene that makes YAP might contribute to cancer

Introgen announces additional broad patent in China

Researchers discover that tumors secrete fatty acids which inhibit the cytotoxic T lymphocytes' ability to kill tumor cells

Researchers characterize the proteome of the human cornea

Inhibitors of cellular enzymes could be developed for SARS treatment

Participants in the gene therapy market discover new ways to improve clinical efficiency and generate revenue

$4.7million grant for research on neuroblastoma

Acetaminophen, when taken as directed, is safe for patients with liver disease

Government in Ontario will pay for three new cancer drugs

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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