Therapeutics News and Research

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First program to apply RNA interference (RNAi) technology to asthma

Sirna Therapeutics, Inc. has announced the first program to apply RNA interference (RNAi) technology to asthma, a highly prevalent, chronic disease accounting for an estimated $13 billion in healthcare costs in the United States, a number which is forecast to grow considerably by the end of the decade.

7 Jan 2005

Stem cells from umbilical cord blood effectively treated heart attacks

When injected into rats' hearts soon after a heart attack, stem cells taken from human umbilical cord blood (HUCB) greatly reduced the size of heart damage and restored pumping function to near normal. This improvement occurred without the need for drugs to prevent the rats' immune system from rejecting the human cells.

5 Jan 2005

Technology that could double the effectiveness of cancer drugs

To identify the best treatment for recurrent ovarian cancer, researchers at Yale School of Medicine are studying a technology called the Yale apoptosis assay in combination with another technology called the ChemoFX assay, which could double the response rate to existing drugs.

4 Jan 2005

Somatic hypermutation (SHM) should prove to be extremely useful in directed protein evolution

Fascinated by the efficient way the human immune system generates a rapid response to create a near-infinite variety of antibodies, researchers have "hijacked" that machinery and used it to evolve a new type of fluorescent protein.

23 Dec 2004

Researchers discover clues to cirrhosis

Researchers at the University of Essex have found new biochemical indicators of cirrhosis in blood plasma which could help detect the disease in its early stages.

20 Dec 2004

Lupus drug may also be useful in treating psoriasis

A new drug candidate previously shown to reduce harmful side effects of the autoimmune disease lupus also may be useful in treating psoriasis.

13 Dec 2004

Importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development

Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for treating the disease, says a researcher from The University of Texas M. D. Anderson Cancer Center.

13 Dec 2004

Zarnestra, a farnesyl transferase inhibitor, can help treat high-risk myelodysplastic syndrome patients

An oral targeted therapy gentle enough to be used by patients in their 70s or 80s is showing benefit in treating high-risk myelodysplastic syndrome (MDS), a pre-leukemic disorder that can progress to acute myelogenous leukemia (AML), according to a study presented at the annual meeting of the American Society of Hematology (ASH).

7 Dec 2004

Adenosine Therapeutics awarded grant to develop drug eluting stents to prevent restenosis

Adenosine Therapeutics announced today the award of a Phase II Small Business Innovation Research (SBIR) grant from the National Institutes of Health.

6 Dec 2004

Scientist develops way to deliver promising genetic tool into living cells

By exploiting an HIV protein that readily traverses cell membranes, Carnegie Mellon University scientists have developed a new way to introduce a gene-like molecule called a peptide nucleic acid (PNA) directly into live mammalian cells, including human embryonic stem (ES) cells.

6 Dec 2004

Alliance to develop and commercialize fully-human anti-anthrax antibody

MDX-1303 was developed by Medarex using its UltiMAb Human Antibody Development System, and this antibody is currently in preclinical development by Medarex for use against human anthrax infection.

6 Dec 2004

Next-generation therapeutics with the potential to successfully treat Lou Gehrig's disease

The hopes of many that ALS (commonly referred to as Lou Gehrig's disease) will one day be a disease of the past, studied in medical textbooks, conquered by the dedication of those who have worked tirelessly to eradicate it might be realized in our lifetime.

6 Dec 2004

Data from phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia

At the 46th Annual Meeting of the American Society of Hematology (ASH) preliminary data were presented from a phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia (MDS).

5 Dec 2004

Oral targeted therapy shows benefit in treating high-risk myelodysplastic syndrome

4 Dec 2004

Fossil record of the human immune system reveals antibodies that block cancer metastasis

A team of researchers at The Scripps Research Institute has reconstructed the "fossil record" of the immune systems of a group of human cancer patients to investigate if they had ever produced antibodies against their disease.

4 Dec 2004

New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

FDA approves Remodulin for the treatment of pulmonary arterial hypertension

United Therapeutics Corporation announced today that the U.S. Food and Drug Administration (FDA) has issued an approval letter for the intravenous use of Remodulin based on data establishing its bioequivalence with the previously approved subcutaneous administration of Remodulin.

24 Nov 2004

Discovery of a new cancer gene, which, when damaged, may promote prostate cancer

Together with an international research team, researchers from VTT Technical Research Centre of Finland have developed an effective method for the screening and identification of genes that under normal conditions suppress cancer growth.

24 Nov 2004

Survey shows need for conservative, drug-free options

A new survey showing that nearly half of all Americans are concerned about the safety of the medical care they receive should send a strong signal to the health and insurance industries that safer non-drug, non-surgical treatments should be considered whenever possible, according to the American Chiropractic Association (ACA).

20 Nov 2004

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

This structure should prove extremely useful in the rational design of small molecule inhibitors of PKCÈ, which has been implicated in T-cell mediated disease processes including inflammation and autoimmunity.

19 Nov 2004

Therapeutics News and Research

First program to apply RNA interference (RNAi) technology to asthma

Stem cells from umbilical cord blood effectively treated heart attacks

Technology that could double the effectiveness of cancer drugs

Somatic hypermutation (SHM) should prove to be extremely useful in directed protein evolution

Researchers discover clues to cirrhosis

Lupus drug may also be useful in treating psoriasis

Importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development

Zarnestra, a farnesyl transferase inhibitor, can help treat high-risk myelodysplastic syndrome patients

Adenosine Therapeutics awarded grant to develop drug eluting stents to prevent restenosis

Scientist develops way to deliver promising genetic tool into living cells

Alliance to develop and commercialize fully-human anti-anthrax antibody

Next-generation therapeutics with the potential to successfully treat Lou Gehrig's disease

Data from phase II study of Trisenox (arsenic trioxide) injection in myelodysplasia

Oral targeted therapy shows benefit in treating high-risk myelodysplastic syndrome

Fossil record of the human immune system reveals antibodies that block cancer metastasis

New research may lead to treatments for atherosclerosis

FDA approves Remodulin for the treatment of pulmonary arterial hypertension

Discovery of a new cancer gene, which, when damaged, may promote prostate cancer

Survey shows need for conservative, drug-free options

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

A new way of characterising biomolecules eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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