Thromboembolism News and Research

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Protamine–heparin complex antibodies raise concerns

Almost a third of patients treated with protamine for heparin reversal during cardiopulmonary bypass develop antibodies to circulating protamine–heparin complexes, study findings suggest.

25 Feb 2013

Dabigatran decreases risk of recurrent venous thromboembolism

New findings from two double-blind, randomized trials, RE-MEDY and RE-SONATE, show that dabigatran 150 mg twice daily reduces the risk of recurrent venous thromboembolism (VTE).

21 Feb 2013

Blood type, blood protein mutations influence thromboembolism risk

Findings from two Danish studies have shown that ABO blood type, both alone and in combination with the presence of factor V and prothrombin mutations, is associated with increases in risk for venous thromboembolism.

20 Feb 2013

Rivaroxaban ruled out for extended thromboprophylaxis

The benefits of extended prophylactic anticoagulation with rivaroxaban in acutely ill hospital patients are outweighed by an increased bleeding risk, shows a study in The New England Journal of Medicine.

14 Feb 2013

Non-O blood type - the most important risk factor for venous thromboembolism

The non-O ABO blood type is the most important risk factor for venous thromboembolism (blood clots in veins), making up 20% of attributable risk for the condition, according to a new study in CMAJ (Canadian Medical Association Journal).

6 Feb 2013

Selective strategy for D-dimer testing in DVT

Selecting certain patients for D-dimer testing appears to be a safe and more efficient way of diagnosing deep vein thrombosis than uniformly testing all patients suspected of having the condition, report researchers.

16 Jan 2013

Link between infections and venous thromboembolism in surgical patients

Despite receiving blood thinners and other clot prevention treatment, some patients still develop potentially lethal blood clots in the first month after their operations anyway, especially if they developed a surgical-site infection while in the hospital, according to results of a study at Johns Hopkins.

16 Jan 2013

Study highlights role of Protein S in maintenance of healthy retina

Researchers at the Hebrew University of Jerusalem, in collaboration with researchers at the Salk Institute in California, have found for the first time that a specific protein is essential not only for maintaining a healthy retina in the eye, but also may have implications for understanding and possibly treating other conditions in the immune, reproductive, vascular and nervous systems, as well as in various cancers.

7 Jan 2013

Thromboprophylaxis does more harm than good in head and neck surgery

Patients undergoing oncologic head and neck surgery do not benefit from thromboprophylaxis, report researchers.

2 Jan 2013

Studies examine current treatment standards for patients with clotting disorders

Studies presented today at the 54th Annual Meeting of the American Society of Hematology (ASH) examine current treatment standards for patients with clotting disorders in an effort to improve outcomes.

11 Dec 2012

Combined oral contraceptives increase risk of blood clots in women with PCOS

Women with polycystic ovary syndrome (PCOS) who are taking combined oral contraceptives have a 2-fold risk of blood clots compared with women without the disorder who take contraceptives, states a study published in CMAJ (Canadian Medical Association Journal).

4 Dec 2012

Aspirin viable alternative to warfarin in preventing clots after joint replacement surgery

If you've had joint replacement surgery, it's likely you've been given warfarin, a common blood thinner and clot-preventer, prior to surgery. While effective, research from the Rothman Institute at Jefferson has shown aspirin to be just as effective in preventing clots, specifically pulmonary emboli, life-threatening blood clots that can develop in the arteries of the lungs following joint replacement surgery.

8 Nov 2012

Low-dose aspirin effective at preventing serious blood clots

Low-dose aspirin is a cheap and effective way to prevent potentially deadly blood clots in the leg or the lungs in patients who have had a previous blood clot a new study shows.

6 Nov 2012

Isis commences ISIS-FXIRx Phase 2 study in knee replacement surgery patients

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 comparator-controlled study evaluating ISIS-FXIRx in patients undergoing knee replacement surgery, also referred to as total knee arthroplasty (TKA).

29 Oct 2012

VTE care improvements may be linked to implementation of treatment guidelines

The quality of care of patients hospitalized with venous thromboembolism (VTE) significantly improved between 2005 and 2009, and researchers suggest these improvements may be due to the implementation of VTE treatment guidelines.

22 Oct 2012

Obesity does not affect VTE risk after knee surgery

Being morbidly obese does not increase the risk for developing venous thromboembolism after total knee arthroplasty surgery, report US researchers.

15 Oct 2012

Best-practices protocol significantly reduces ventilator-associated pneumonia

An intensive care unit-initiated protocol implementing “best practices” significantly reduces ventilator-associated pneumonia, research shows.

8 Oct 2012

VTE risk highlighted for rheumatoid arthritis patients

Individuals with rheumatoid arthritis are at an increased risk for venous thromboembolism, research confirms.

8 Oct 2012

Patients with RA more likely to develop venous thromboembolism

A study that included more than 45,000 residents of Sweden with rheumatoid arthritis finds that individuals with this disease had an associated higher risk of venous thromboembolism (a blood clot that forms within a vein), and that this elevated risk was stable for 10 years after the time of diagnosis, according to a study in the October 3 issue of JAMA.

3 Oct 2012

Warfarin therapy should not be stopped completely after GI bleeding

The decision to not resume warfarin therapy following a gastrointestinal bleeding event is linked to an increased risk for thrombosis and mortality, researchers suggest.

27 Sep 2012