Top Down Approach News and Research

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MRI innovation to unveil iron homeostasis in the human brain

Researchers demonstrated a MRI method sensitive to the live brain's iron homeostasis (the r1-r2 extent of relaxation or relaxivity).

14 Sep 2023

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Pittsburgh Analytical Chemistry Award, Neil Kelleher, about his work in top-down proteinomics.

From Pittcon 26 May 2023

Can monkeypox spread through contaminated food?

In a recent study published in the journal Microbial Risk Analysis, a team of researchers from France performed a qualitative risk assessment to determine the probability of transmission of monkeypox through the handling and consumption of food.

1 Nov 2022

Researchers discover mechanism for congenital disorders of glycosylation

Greenwood Genetic Center researchers are reporting the discovery of a mechanism that contributes to the tissue phenotypes seen in PMM2-CDG, the most common of the congenital disorders of glycosylation (CDGs).

8 Dec 2021

UCR researchers gauge social responsibility in reducing COVID-19 spread

Uncertainty and anxiety generated by the COVID-19 pandemic motivated social psychologist Evelyn Vázquez at the University of California, Riverside, to collaborate with UCR Healthy Campus on a study to identify safety measures and public health messaging that reduce the spread of the coronavirus within campus communities.

24 Aug 2021

Government mistrust plays a vital role in slowing down child vaccination progress in Africa

Mistrust in local and national government plays a significant role in slowing down child vaccination progress in Africa - the continent home to half of the world's unvaccinated and under-vaccinated children, new research reveals.

30 Apr 2021

Minuscule tracking devices show how living cells change with time

For the first time, scientists have introduced minuscule tracking devices directly into the interior of mammalian cells, giving an unprecedented peek into the processes that govern the beginning of development.

20 Oct 2020

Biomedical engineers create artificial organelles to control biological function in cells

Biomedical engineers at Duke University have demonstrated a method for controlling the phase separation of an emerging class of proteins to create artificial membrane-less organelles within human cells.

4 Aug 2020

Minuscule tracking devices give unprecedented peek into how cells change with time

26 May 2020

Three studies show how tumors hijack the immune system to develop radiotherapy resistance

More than a decade ago, radiation oncologists noticed a nifty phenomenon: Sometimes radiation used locally against a tumor could excite the immune system to attack cancer systemically throughout the body.

17 Apr 2019

Urban mosquito control with help from scientists

Thanks to an innovative mosquito control approach developed at Rutgers University-New Brunswick, residents in several Maryland neighborhoods reduced populations of invasive Asian tiger mosquitoes by an impressive 76 percent, on average.

25 Oct 2018

Researchers use 'top-down proteomics' strategy to get new insights into cancer

When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch jams into the "on" position, allowing cells to proliferate uncontrollably.

18 Apr 2018

Why Should We Weigh Every Protein in the Human Body?

Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level.

From Pittcon 5 Jan 2018

‘Local’ learning health system can improve clinical quality while reducing costs

Providing high-quality patient care while reducing costs is a significant goal in the current health care reform environment.

20 Dec 2016

Making parents healthier before conception could be key to preventing obesity in future generations

The key to preventing obesity in future generations is to make their parents healthier before they conceive, leading health researchers suggest.

13 Oct 2016

Vanderbilt researchers use cotton candy machines to produce artificial capillary system

For several years, Leon Bellan, assistant professor of mechanical engineering at Vanderbilt University, has been tinkering with cotton candy machines, getting them to spin out networks of tiny threads comparable in size, density and complexity to the patterns formed by capillaries - the tiny, thin-walled vessels that deliver oxygen and nutrients to cells and carry away waste.

9 Feb 2016

First Edition: October 4, 2012

Kaiser Health News staff writer Phil Galewitz, working in collaboration with the PBS Newshour, reports: "The future of Medicaid -- the state-federal workhorse of the nation's health system that provides health coverage to the poorest and sickest Americans -- hangs in the balance on Election Day. President Barack Obama and Republican nominee Mitt Romney have vastly different approaches to the program."

4 Oct 2012

Researchers report one-third cut in the rate of lethal SSIs after colorectal operations

A patient safety team including researchers in the Johns Hopkins Armstrong Institute for Patient Safety and Quality reported a one-third cut in the rate of costly and potentially lethal surgical site infections (SSIs) following colorectal operations after requiring use of a simple safety checklist and urging caregivers to speak up if they see potentially unsafe practices.

2 Aug 2012

Early intervention of biologic therapies improves outcome for Crohn's disease

A large-scale study of medical claims data shows that introducing sophisticated biologic therapies early in the course of treatment for Crohn's disease improves response to medication and reduces the need for surgery.

18 Apr 2012

Virginia Tech receives NIH grant to develop new systems biology approaches for cell study

The National Institutes of Health has awarded Virginia Tech researchers a $2.13 million grant to develop new systems biology approaches to study cells, one of the most basic units of life.

5 May 2011