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Research offers first structural insights into 'client' protein shape in chaperone presence

In the constantly morphing field of protein structure, scientists at The Scripps Research Institute offer yet another surprise: a common "chaperone" protein in cells thought to help other proteins fold has been shown instead to loosen them.

4 Apr 2011

Rsearchers define new step that controls programmed cell death in cancer cells

When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death.

2 Apr 2011

Loss of SKIP sensitizes cancer cells to apoptotic effects of DNA damage-inducing anticancer drugs

When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death. In contrast to other stress-induced genes, which dispense with the regular transcriptional entourage, p21Cip1 still requires SKIP, a transcription elongation factor that also helps with the editing of transcripts, to be expressed, found researchers at the Salk Institute for Biological Studies.

2 Apr 2011

Two new studies on cancer

Last year, a research team at the University of North Carolina at Chapel Hill discovered one way the protein Tet 1 helps stem cells keep their pluripotency-the unique ability to become any cell type in the body.

31 Mar 2011

Metabolic Solutions initiates MSDC-0602 Phase 2a trial in patients with type 2 diabetes

Metabolic Solutions Development Company, a drug discovery and development company exploiting novel molecular targets to treat metabolic diseases, announced today that it has launched a Phase 2a trial for MSDC-0602, the company's second drug candidate for the treatment of type 2 diabetes.

30 Mar 2011

Researchers discover novel gene regulation mechanism that contributes to HCC development

Researchers at Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine have discovered a novel mechanism in gene regulation that contributes to the development of a form of liver cancer called hepatocellular carcinoma.

23 Mar 2011

Modified mRNA raises hope for safe and effective cancer drugs

Modern gene therapies raise hopes of combating many diseases until now considered terminal. Nowadays, however, the methods are expensive and carry a risk of severe complications.

18 Mar 2011

Vitamin A may play key role in sperm cell formation and development of central nervous system

In a recently-published study mapping the structure and function of the so-called "orphan" nuclear receptor TR4, Van Andel Research Institute (VARI) investigators suggest that Vitamin A may play a more direct role than was previously known in certain physiological functions including sperm cell formation and the development of the central nervous system.

18 Mar 2011

Bacteria more likely to adopt 'loner' genes

A new study of more than three dozen bacteria species - including the microbes responsible for pneumonia, meningitis, stomach ulcers and plague - settles a longstanding debate about why bacteria are more likely to steal some genes than others.

17 Mar 2011

Oxford Nanopore selects Accelrys Pipeline Pilot NGS Collection as preferred analysis platform

Accelrys, Inc., a leading scientific enterprise R&D software and services company, today announced the signing of a partnership agreement with Oxford Nanopore Technologies Ltd. Under the terms of the partnership, Accelrys and Oxford Nanopore will develop software to enable complex, real-time analyses of experimental data produced by the Oxford Nanopore single molecule analysis system.

From Oxford Nanopore Technologies 16 Mar 2011

Scientists identify unique function of Twist1 in tumor metastasis

In the early stages of human embryogenesis, a transcription factor called Twist1 plays a key regulatory role in how the embryo assumes form and function. Much later in life, however, researchers at the University of California, San Diego School of Medicine, say Twist1 can re-emerge, taking a darker and more deadly turn.

15 Mar 2011

Elevated p21 expression may block key steps in viral life cycle

Elevated levels of p21, a protein best known as a cancer fighter, may be involved in the ability of a few individuals to control HIV infection with their immune system alone.

15 Mar 2011

New research: Fzd9 receptor can stimulate bone formation

New research shows that the Wnt receptor Frizzled-9 promotes bone formation, providing a potential new target for the treatment of osteoporosis. The study appears online on March 14 in The Journal of Cell Biology.

15 Mar 2011

Autoimmune response mediated by T lymphocytes may play vital role in pathogenesis of biliary atresia

Biliary atresia (BA) is an inflammatory obliterative cholangiopathy with unknown etiology, leading to progressive fibrosis and cirrhosis. Microarray technology, emerged as an indispensable research tool for gene expression profiling, has been used to study the mechanism underlying BA, and allows the simultaneous analysis of thousands of transcripts within a single experiment.

9 Mar 2011

New discovery in childhood respiratory disease

Researchers have identified a critical part of the process by which one of the world's most common and dangerous early childhood infections, respiratory syncytial virus, causes disease.

8 Mar 2011

Fumaric acid salts may protect against Multiple Sclerosis

Fumaric acid salts have been in use against severe psoriasis for a long time. About ten years ago, researchers in Bochum speculated that they may also have a favourable effect on Multiple Sclerosis as a result of their TH2 polarizing mechanisms.

8 Mar 2011

Two studies show how laminin plays a central role in breast cancer development

Laminin, long thought to be only a structural support protein in the microenvironment of breast and other epithelial tissues, is "famous" for its cross-like shape.

8 Mar 2011

Article outlines role of transcriptional mutagenesis in tumor development

DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

5 Mar 2011

Scientist discovers new mechanism for regulation of gene expression

Dr. David Levin, Professor of Molecular & Cell Biology at Boston University Henry M. Goldman School of Dental Medicine and Professor of Microbiology at Boston University School of Medicine discovered recently a novel, evolutionarily conserved mechanism for the regulation of gene expression.

4 Mar 2011

New insight: p53 protein controls molecular crossroads in glucose metabolic pathway

The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are made into proteins.

3 Mar 2011

Transcription News and Research

Research offers first structural insights into 'client' protein shape in chaperone presence

Rsearchers define new step that controls programmed cell death in cancer cells

Loss of SKIP sensitizes cancer cells to apoptotic effects of DNA damage-inducing anticancer drugs

Two new studies on cancer

Metabolic Solutions initiates MSDC-0602 Phase 2a trial in patients with type 2 diabetes

Researchers discover novel gene regulation mechanism that contributes to HCC development

Modified mRNA raises hope for safe and effective cancer drugs

Vitamin A may play key role in sperm cell formation and development of central nervous system

Bacteria more likely to adopt 'loner' genes

Oxford Nanopore selects Accelrys Pipeline Pilot NGS Collection as preferred analysis platform

Scientists identify unique function of Twist1 in tumor metastasis

Elevated p21 expression may block key steps in viral life cycle

New research: Fzd9 receptor can stimulate bone formation

Autoimmune response mediated by T lymphocytes may play vital role in pathogenesis of biliary atresia

New discovery in childhood respiratory disease

Fumaric acid salts may protect against Multiple Sclerosis

Two studies show how laminin plays a central role in breast cancer development

Article outlines role of transcriptional mutagenesis in tumor development

Scientist discovers new mechanism for regulation of gene expression

New insight: p53 protein controls molecular crossroads in glucose metabolic pathway

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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