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Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

Using synthetic biology to develop smarter cell therapies for cancer patients

We are embarking on an unprecedented era of therapeutic development enabled by live cell engineering.

31 Oct 2023

Scientists develop gene therapy approach for rare paralyzing disease

The 50 families stretch from the Netherlands and the United Kingdom to the United States and China. Each family has a child who is paralyzed from a mutation in a single gene named Contactin-Associated Protein 1 (Cntnap1).

20 Oct 2023

Review highlights the potential mechanistic links between COVID-19 and Alzheimer's disease

The various neurological symptoms that patients with COVID-19 have experienced suggest that viral infections may increase the risk of neurodegeneration, which could in turn contribute to the development of conditions such as Alzheimer's disease (AD).

18 Oct 2023

Towards xenotransplantation: Genetically altered pig kidneys prove viable in non-human primates

Researchers used a genetically engineered porcine donor to develop kidney grafts.

11 Oct 2023

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most currently known sarbecoviruses.

27 Sep 2023

New form of cellular immunotherapy shows promise against brain tumors in mice

Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) successfully tested a new form of cellular immunotherapy against brain tumors in mice for the first time.

26 Sep 2023

Researchers identify key mechanisms to address future treatments for hereditary blindness

There are still many enigmas about the mechanism of action of the CERKL gene, which causes retinitis pigmentosa and other hereditary vision diseases.

18 Sep 2023

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

Researchers conducted the phase 1 trial of orally-administered senolytic therapy comprising quercetin (Q) and dasatinib (D) for symptomatic and early-stage Alzheimer's disease (AD) patients.

8 Sep 2023

Aligning Rhythms, Defying Alzheimer's: Intermittent Fasting's Role in Combating Alzheimer's Disease Neurodegeneration

News Medical interviewed Dr Paula Desplats, an Associate Professor of Neurosciences at the University of California San Diego.

1 Sep 2023

New drug candidate reduces inflammation and improves memory in Alzheimer's mouse models

Though drug developers have achieved some progress in treating Alzheimer's disease with medicines that reduce amyloid-beta protein, other problems of the disease including inflammation, continue unchecked.

29 Aug 2023

Time-restricted feeding reverses Alzheimer's symptoms in mice, offers new hope for accessible treatment

Researchers explore the therapeutic potential of circadian-modulating interventions to treat Alzheimer’s disease.

27 Aug 2023

Platelets play a role in mediating the rejuvenating effects of exercise during physiological brain ageing

The impacts of physical activity on the neuronal formation and prevent age-related cognitive decay.

22 Aug 2023

Novel multi-epitope subunit vaccine induces robust immune response against Epstein-Barr virus

Scientists have developed a lymph node-targeted multi-epitope subunit vaccine that induces strong humoral and cellular immune responses against EBV in mice.

14 Aug 2023

Neoantigen discovery sheds light on cancer immunogenicity

Researchers reported a proteogenomic approach to investigate fresh solid melanoma tumor material.

4 Aug 2023

Dopamine neurons may play a bigger role in motor control than previously thought

Dopamine: It's not just for rewards anymore. In a new Northwestern University-led study, researchers identified and recorded from three genetic subtypes of dopamine neurons in the midbrain region of a mouse model.

3 Aug 2023

Study sheds light on mechanisms behind a rare disease found almost exclusively in boys

A University of Ottawa-led research team has published rigorous new research that advances a quest to understand a puzzling – and heartbreaking – ultra-rare disease that's found almost exclusively in boys.

3 Aug 2023

Study finds α5 integrin as a potential therapeutic target in amyotrophic lateral sclerosis

Researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral sclerosis (ALS).

3 Aug 2023

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

Rockefeller researchers reveal the mechanisms behind malignant turn of events in cancer

Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as a single layer of epidermal progenitor cells.

31 Jul 2023

Transgenic News and Research

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Using synthetic biology to develop smarter cell therapies for cancer patients

Scientists develop gene therapy approach for rare paralyzing disease

Review highlights the potential mechanistic links between COVID-19 and Alzheimer's disease

Towards xenotransplantation: Genetically altered pig kidneys prove viable in non-human primates

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

New form of cellular immunotherapy shows promise against brain tumors in mice

Researchers identify key mechanisms to address future treatments for hereditary blindness

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

Aligning Rhythms, Defying Alzheimer's: Intermittent Fasting's Role in Combating Alzheimer's Disease Neurodegeneration

New drug candidate reduces inflammation and improves memory in Alzheimer's mouse models

Time-restricted feeding reverses Alzheimer's symptoms in mice, offers new hope for accessible treatment

Platelets play a role in mediating the rejuvenating effects of exercise during physiological brain ageing

Novel multi-epitope subunit vaccine induces robust immune response against Epstein-Barr virus

Neoantigen discovery sheds light on cancer immunogenicity

Dopamine neurons may play a bigger role in motor control than previously thought

Study sheds light on mechanisms behind a rare disease found almost exclusively in boys

Study finds α5 integrin as a potential therapeutic target in amyotrophic lateral sclerosis

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

Rockefeller researchers reveal the mechanisms behind malignant turn of events in cancer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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