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Researchers unravel mechanisms that enable accumulation of tumour promoting protease in stressed cancer cells

A mechanism beyond the level of gene regulation, which is often the underlying reason for changes in protein levels, does enable the strong accumulation of a tumour promoting protease in stressed cancer cells. The group of BIOSS researcher Prof. Dr. Thomas Reinheckel teamed up with BIOSS investigator Prof. Dr. Sabine Rospert and their colleagues from the University Medical Center Freiburg, Prof. Dr. Elmar Stickeler and Dr. Peter Bronsert, in order to unravel mechanisms by which stress-resistant production of cancer promoting proteins occurs.

6 Jul 2015

Review article provides in depth survey of studies focusing on retinoblastoma protein's role in apoptosis

Retinoblastoma protein RB1, which is named after a form of pediatric tumor of the eye, is among the most common genetically regulated cellular proteins to malfunction in human cancer. RB1 was also the first tumor suppressor gene to be identified and its modes of inactivation in retinoblastoma tumors provided the basis for the ground-breaking two-hit hypothesis by the geneticist Alfred G. Knudson in the 70s, according to which cancer is due to the accumulation of multiple 'hits' or mutations in certain genes.

3 Jul 2015

University of Cambridge, AstraZeneca announce new joint schemes to support PhD scholarships, clinical lectureships

AstraZeneca and the University of Cambridge today announced three new joint schemes to support more than 80 PhD scholarshipsand eight clinical lectureships over the next five years spanning translational science, basic and clinical research.

30 Jun 2015

Researchers discover mechanism that regulates metabolism

The protein complex mTORC1 is a central regulator of cell metabolism. In the active state, it stimulates anabolic processes and increases the production and storage of proteins and lipids. Researchers from the German Leibniz Institute for Age Research in Jena and the Dutch Ageing Institute ERIBA in Groningen discovered a mechanism how mTORC1 regulates metabolism: It controls the expression of a specific variant of the transcriptional regulator C/EBPβ.

29 Jun 2015

People with specific gene variant at greater risk of developing depressions

People born with a particular gene variant have a greater risk of developing depressions, a recent study from the Department of Psychology at The University of Oslo shows.

29 Jun 2015

Dr. Maurizio D'Incalci to receive Pezcoller-Prodi Award in Scientific Career

Dr. Maurizio D'Incalci, MD, Ph.D., will receive an award in recognition of his scientific career at the new Special Conference on Anticancer Drug Action and Drug Resistance: from Cancer Biology to the Clinic organized by the European Association of Cancer Research, the American Association of Cancer Research and the Italian Cancer Society and that will be held in Florence, Italy, June 20-23.

23 Jun 2015

UT System's clinical trials network can help get more effective drugs to patients faster

The University of Texas System has launched a groundbreaking clinical trials network to ensure drugs and therapies developed by researchers at UT institutions get to patients faster and are effective.

23 Jun 2015

New Christian Doppler Laboratory for Clinical Molecular MR Imaging opens at MedUni Vienna

Today the new Christian Doppler Laboratory for Clinical Molecular MR Imaging (MOLIMA) was opened at the University Clinic of Radiology and Nuclear Medicine at MedUni Vienna. Its aim is to bring about a significant improvement in the prognosis or course of a disease. The research institute, which is funded by the Federal Ministry of Science, Research and Economy, develops high-resolution, quantitative imaging techniques to allow disease to be identified at an even earlier stage.

19 Jun 2015

Bayer HealthCare, Johns Hopkins University to jointly develop new ophthalmic therapies targeting retinal diseases

The Johns Hopkins University and Bayer HealthCare have entered into a five-year collaboration agreement to jointly develop new ophthalmic therapies targeting retinal diseases. The goal of the strategic research alliance is to accelerate the translation of innovative approaches from the laboratory to the clinic, ultimately offering patients new treatment options for several retinal diseases.

17 Jun 2015

Vitamin D supplementation may treat Crohn’s disease

New research published in this month’s edition of United European Gastroenterology Journal suggests that supplementation with vitamin D may impact on the intestinal barrier dysfunction associated with Crohn’s disease, and could have a role in the treatment of the condition.

15 Jun 2015

Vitamin D supplementation may affect intestinal barrier dysfunction associated with Crohn's disease

New research published in this month's edition of United European Gastroenterology journal suggests that supplementation with vitamin D may impact on the intestinal barrier dysfunction associated with Crohn's disease, and could have a role in the treatment of the condition.

13 Jun 2015

Ludwig Cancer Research announces opening of new branch in Lausanne, Switzerland

Ludwig Cancer Research announced today that it is opening a new Branch in Lausanne, Switzerland. The Branch will be focused primarily on applied cancer immunology and the design of novel molecular and cell-based immunotherapies. It will also develop technologies enabling the efficient, safe application of those therapies to as many patients as possible.

12 Jun 2015

Study seeks to determine environmental factors that protect against asthma, allergies

Researchers in the University of Arizona's BIO5 Institute have entered into a collaboration with Johnson & Johnson Consumer & Personal Products and Janssen Biotech Inc. to leverage foundational discovery research aimed at determining environmental factors that underlie asthma and allergies.

12 Jun 2015

Scientists and clinicians from across the UK come together to address treatment of brain tumors

In an exciting step forward to finding a cure for brain tumours, which kill more children and adults under the age of 40 than any other cancer, the national charity Brain Tumour Research brought together a group of leading brain tumour scientists and clinicians to help accelerate vital research into this devastating disease.

11 Jun 2015

QUT cancer and eye researchers named in Queen's Birthday honours

Professor Clements is honoured for her outstanding contribution to biomedical research, particularly prostate cancer research, and for her success in generating ongoing funding to support the establishment of critically-needed national medical research facilities.

10 Jun 2015

Novel virtual laboratory works to improve population health, prepare future transformational leaders

A newly published paper describes and evaluates the Indiana University Center for Health Innovation and Implementation Science, a novel virtual laboratory employing the tools of implementation science to improve population health, lower costs of its delivery and prepare the future health care transformational leaders.

9 Jun 2015

BioLight Life Sciences reports operational and financial results for Q1 2015

BioLight Life Sciences Investments, a firm that invests in, manages and commercializes biomedical innovations in ophthalmology and cancer diagnostics, today reported operational and financial results for the first quarter ended March 31, 2015.

1 Jun 2015

BiondVax provides update on financial results for first quarter 2015

BiondVax Pharmaceuticals Ltd., a clinical stage biopharmaceutical company focused on developing and commercializing immunomodulation therapies for infectious diseases, today announced its financial results for the first quarter of 2015 and provided a business update.

1 Jun 2015

HarkerBIO, AMRI sign collaborative agreement to market structure-based drug discovery services

Albany Molecular Research Inc. (NASDAQ: AMRI) announced today that it has signed a collaborative agreement with biotechnology company HarkerBIO LLC to co-market their structure-based drug discovery services to global pharmaceutical and biotechnology clients.

1 Jun 2015

Many Americans unclear whether domestic health insurance plan works outside the US

A surprising number of Americans are unclear whether their health insurance works outside the US, according to a new InsureMyTrip survey. Over twenty-five percent polled were not sure whether their domestic health insurance plan would cover any doctor or hospital visits while traveling outside the country.

25 May 2015

Translation News and Research

Researchers unravel mechanisms that enable accumulation of tumour promoting protease in stressed cancer cells

Review article provides in depth survey of studies focusing on retinoblastoma protein's role in apoptosis

University of Cambridge, AstraZeneca announce new joint schemes to support PhD scholarships, clinical lectureships

Researchers discover mechanism that regulates metabolism

People with specific gene variant at greater risk of developing depressions

Dr. Maurizio D'Incalci to receive Pezcoller-Prodi Award in Scientific Career

UT System's clinical trials network can help get more effective drugs to patients faster

New Christian Doppler Laboratory for Clinical Molecular MR Imaging opens at MedUni Vienna

Bayer HealthCare, Johns Hopkins University to jointly develop new ophthalmic therapies targeting retinal diseases

Vitamin D supplementation may treat Crohn’s disease

Vitamin D supplementation may affect intestinal barrier dysfunction associated with Crohn's disease

Ludwig Cancer Research announces opening of new branch in Lausanne, Switzerland

Study seeks to determine environmental factors that protect against asthma, allergies

Scientists and clinicians from across the UK come together to address treatment of brain tumors

QUT cancer and eye researchers named in Queen's Birthday honours

Novel virtual laboratory works to improve population health, prepare future transformational leaders

BioLight Life Sciences reports operational and financial results for Q1 2015

BiondVax provides update on financial results for first quarter 2015

HarkerBIO, AMRI sign collaborative agreement to market structure-based drug discovery services

Many Americans unclear whether domestic health insurance plan works outside the US

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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