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Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Aileron Therapeutics, Inc. today announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.

7 May 2013

Researchers issue statement regarding use of unproven stem cell therapies

An international group of leading stem cell researchers has issued a statement that specifies concerns about the development and use of unproven stem cell therapies.

4 May 2013

PET/CT may enhance detection of inflammatory bowel diseases in the future

Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, may be detected and monitored more effectively in the future with positron emission tomography/computed tomography, according to research published in the May issue of The Journal of Nuclear Medicine.

2 May 2013

Penn Medicine's Brian L. Strom named 2013 Career Distinguished Investigator

Brian L. Strom, MD, MPH, the executive vice dean for Institutional Affairs in the Perelman School of Medicine at the University of Pennsylvania and professor of Biostatistics and Epidemiology, was recently presented with a National Award for Career Achievement and Contribution to Clinical and Translational Science at the Translational Science 2013 meeting in Washington, D.C.

30 Apr 2013

Novel strategy for characterizing RNAs transported from nerve cell to synapse

Despite decades of research, relatively little is known about the identity of RNA molecules that are transported as part of the molecular process underpinning learning and memory.

26 Apr 2013

Scientists call for global action against the use of synthetics chemicals in consumer products and pesticides

Today, a group of influential scientists called for swift action by the UN system to prevent harm from a wide variety of synthetic chemicals in consumer products and pesticides that play a role in increased incidences of reproductive diseases, cancer, obesity, and type-2 diabetes worldwide.

26 Apr 2013

Research on miRNAs offers new therapeutic potential to fight diseases

RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes - from development to physiology to stress response.

26 Apr 2013

Promising development for women with triple-negative breast cancer

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer.

24 Apr 2013

Pediatric nurse scientist awarded AACN Impact Research Grant

The American Association of Critical-Care Nurses recently awarded a $50,000 AACN Impact Research Grant to Martha A.Q. Curley, RN, PhD, FAAN, a leading clinical scientist in pediatric critical care nursing.

24 Apr 2013

AACN awards Impact Research Grant to Detroit palliative care expert

The American Association of Critical-Care Nurses recently awarded an AACN Impact Research Grant to Margaret "Meg" Campbell, RN, PhD, FAAN, a nationally known expert in hospital-based palliative care and end-of-life issues.

24 Apr 2013

Study examines effectiveness of leadership training programs in academic medical centres

Academic medical centres invest considerable time, money and other resources in leadership training programs, yet there is no evidence such programs work, a new study has found.

23 Apr 2013

IMRT reduces feelings of dry mouth in patients with head and neck cancers

Geneva, Switzerland: Researchers have shown for the first time that it is possible to reduce the distressing symptoms of dry mouth in patients treated with radiotherapy for head and neck cancers if the radiation dose to a salivary gland (called the submandibular gland) on the opposite side to the tumour is kept to the minimum.

22 Apr 2013

Abnormal protein translation leads to Fragile X ataxia, study finds

A bizarre twist on the usual way proteins are made may explain mysterious symptoms in the grandparents of some children with mental disabilities.

19 Apr 2013

Review finds drugs, vitamin supplements may not help prevent cognitive decline in seniors

A review of published research has found no evidence that drugs, herbal products or vitamin supplements help prevent cognitive decline in healthy older adults.

16 Apr 2013

Researchers develop nanodiamond delivery system for triple-negative breast cancer

Recently, doctors have begun to categorize breast cancers into four main groups according to the genetic makeup of the cancer cells. Which category a cancer falls into generally determines the best method of treatment.

16 Apr 2013

Researchers discover new technique that directly converts skin cells into functional brain cells

Researchers at Case Western Reserve School of Medicine have discovered a technique that directly converts skin cells to the type of brain cells destroyed in patients with multiple sclerosis, cerebral palsy and other so-called myelin disorders.

15 Apr 2013

Death of heart tissue could be prevented with new medicines, say TUSM scientists

A major factor in the advance of heart disease is the death of heart tissue, a process that a team of scientists at Temple University School of Medicine's Center for Translational Medicine think could be prevented with new medicines.

15 Apr 2013

Gabriel Hortobagyi recognized with AACR-MICR Jane Cooke Wright Lectureship

Gabriel Hortobagyi, M.D., professor in the Department of Breast Medical Oncology at The University of Texas MD Anderson Cancer Center, will receive the Jane Cooke Wright Lectureship from the American Association for Cancer Research and its Minorities in Cancer Research membership group.

12 Apr 2013

SAGIC researchers aim to compile genetic, genomic and phenotypic data of sleep apnea patients

As more and more data indicate that sleep apnea is linked with cardiovascular disease, stroke, diabetes and even an increase in deaths related to car accidents, an international consortium spanning five continents is working together to unravel the genetic basis for the condition.

11 Apr 2013

Tumors with excess copies of MYCN highly sensitive to BET bromodomain inhibitors, researchers find

An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists will report at the annual meeting of the American Association for Cancer Research in Washington, April 6-10.

10 Apr 2013

Translation News and Research

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Researchers issue statement regarding use of unproven stem cell therapies

PET/CT may enhance detection of inflammatory bowel diseases in the future

Penn Medicine's Brian L. Strom named 2013 Career Distinguished Investigator

Novel strategy for characterizing RNAs transported from nerve cell to synapse

Scientists call for global action against the use of synthetics chemicals in consumer products and pesticides

Research on miRNAs offers new therapeutic potential to fight diseases

Promising development for women with triple-negative breast cancer

Pediatric nurse scientist awarded AACN Impact Research Grant

AACN awards Impact Research Grant to Detroit palliative care expert

Study examines effectiveness of leadership training programs in academic medical centres

IMRT reduces feelings of dry mouth in patients with head and neck cancers

Abnormal protein translation leads to Fragile X ataxia, study finds

Review finds drugs, vitamin supplements may not help prevent cognitive decline in seniors

Researchers develop nanodiamond delivery system for triple-negative breast cancer

Researchers discover new technique that directly converts skin cells into functional brain cells

Death of heart tissue could be prevented with new medicines, say TUSM scientists

Gabriel Hortobagyi recognized with AACR-MICR Jane Cooke Wright Lectureship

SAGIC researchers aim to compile genetic, genomic and phenotypic data of sleep apnea patients

Tumors with excess copies of MYCN highly sensitive to BET bromodomain inhibitors, researchers find

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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