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CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

In a landmark study, an international consortium led by researchers at Children's Hospital of Philadelphia (CHOP) published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).

24 Apr 2024

NYU Langone surgeons perform first combined mechanical heart pump and gene-edited pig kidney transplant surgery

Surgeons at NYU Langone Health performed the first combined mechanical heart pump and gene-edited pig kidney transplant surgery.

24 Apr 2024

Research explores how moms' obesity reprograms babies

Research increasingly suggests that when a woman with obesity becomes pregnant, a process of "fetal reprogramming" increases the risk that her baby will face problems like obesity, Type 2 diabetes and liver disease earlier in life.

23 Apr 2024

Research highlights emergence of immune-evasive SARS-CoV-2 variants in immunocompromised patients

New research to be presented at next week's ESCMID Global Congress (formerly ECCMID) in Barcelona, Spain (27-30 April) highlights the risk of new immune-evasive SARS-CoV-2 variants emerging in immunocompromised patients.

18 Apr 2024

FDA announces recall of heart pumps linked to deaths and injuries

A pair of heart devices linked to hundreds of injuries and at least 14 deaths has received the FDA's most serious recall, the agency announced Monday.

16 Apr 2024

MD Anderson and CureVac collaborate on mRNA-based cancer vaccines

The University of Texas MD Anderson Cancer Center and CureVac N.V. today announced a co-development and licensing agreement to develop novel mRNA-based cancer vaccines.

16 Apr 2024

Kidney-CHAMP framework provides equitable access and overcomes barriers to kidney disease care

Manisha Jhamb, M.D., launched the Kidney-CHAMP study five years ago because she saw a looming tsunami of chronic kidney disease cases. She was pulled to find a way to assist the primary care physicians upon whom this burden would fall.

16 Apr 2024

NYU Langone achieves highest-quality kidney and lung transplant results in the U.S.

The NYU Langone Transplant Institute had the highest-quality kidney and lung transplant outcomes in the nation in 2023, according to federal quality data, while its heart and liver transplant programs reached new heights last year.

15 Apr 2024

Bio-Rad announces collaboration agreement with oncocyte to commercialize transplant monitoring with droplet digital PCR

Collaboration Aims to Provide Researchers Cutting-Edge Tools to Enable Transformational Monitoring of Key Biomarkers in Solid Tissue Transplants.

From Bio-Rad Laboratories 15 Apr 2024

Normothermic regional perfusion could increase the number of patients receiving lung transplants

Re-perfusing the lungs of an organ donor after the heart has irreversibly stopped beating with a technique called normothermic regional perfusion (TA-NRP) could potentially increase the number of patients receiving lung transplants, according to researchers at the Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) in Prague.

13 Apr 2024

Heart transplant recipient's journey: From patient to advocate

Glen Kelley's journey as a heart transplant recipient came full circle today in Prague, as he addressed attendees of the Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), including members of his own care teams.

12 Apr 2024

Innovative cancer treatment approach yields promising results in pediatric patients

Researchers have developed a functional precision medicine approach that targets cancer by combining genetic testing with a new way to test individual drugs on tumor samples.

12 Apr 2024

Robotic lung transplantation: A paradigm shift in surgical approach

While debating the pros and cons of robotically assisted lung transplantation, Albert Jauregui, MD, PhD told attendees at the Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), today in Prague that the time for robotic surgery is now.

12 Apr 2024

Revolutionizing heart failure treatment: Advances in mechanical circulatory support devices

The same technology that enables a bullet train to travel at speeds up to 200 mph without touching its rails now keeps a failing heart pumping-;and in the near future, it will do so via a wireless power connection.

12 Apr 2024

Xenotransplantation poised to become a clinical reality soon

Speaking today at the Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation in Prague, Muhammad Mohiuddin, MBBS, said xenotransplantation, hailed as the future of organ transplantation, is poised to become a clinical reality within the next several years.

12 Apr 2024

AI will help heart transplant surgeons to better assess the factors impacting patient outcomes

Artificial intelligence will significantly impact the heart transplantation process by helping physicians better assess the complex factors impacting patient outcomes, according to researchers at today's Annual Meeting and Scientific Sessions of the International Society of Heart and Lung Transplantation (ISHLT) in Prague.

10 Apr 2024

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Adding a personalized anti-tumor vaccine to standard immunotherapy is safe and about twice as likely to shrink cancer as standard immunotherapy alone for patients with hepatocellular carcinoma, the most common type of liver cancer, according to a clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center and its Convergence Institute.

8 Apr 2024

Impella CP pump shows survival benefit in cardiogenic shock

Implantation of the Impella CP micro-axial flow pump in the hours after a heart attack significantly increased the rate of survival at six months among people suffering cardiogenic shock, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Study provides insights on lung transplantation in advanced age candidates

Data from the International Society for Heart and Lung Transplantation (ISHLT) indicates that the proportion of recipients aged 66 and above has risen to 19% by 2017.

8 Apr 2024

Interatrial shunt may offer differential benefits based on heart failure type

Patients with heart failure who had a small shunt inserted between the heart's left and right atria did not see any significant benefits overall compared with those who received a placebo procedure after a median of 22 months follow-up, in a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Transplant News and Research

CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

NYU Langone surgeons perform first combined mechanical heart pump and gene-edited pig kidney transplant surgery

Research explores how moms' obesity reprograms babies

Research highlights emergence of immune-evasive SARS-CoV-2 variants in immunocompromised patients

FDA announces recall of heart pumps linked to deaths and injuries

MD Anderson and CureVac collaborate on mRNA-based cancer vaccines

Kidney-CHAMP framework provides equitable access and overcomes barriers to kidney disease care

NYU Langone achieves highest-quality kidney and lung transplant results in the U.S.

Bio-Rad announces collaboration agreement with oncocyte to commercialize transplant monitoring with droplet digital PCR

Normothermic regional perfusion could increase the number of patients receiving lung transplants

Heart transplant recipient's journey: From patient to advocate

Innovative cancer treatment approach yields promising results in pediatric patients

Robotic lung transplantation: A paradigm shift in surgical approach

Revolutionizing heart failure treatment: Advances in mechanical circulatory support devices

Xenotransplantation poised to become a clinical reality soon

AI will help heart transplant surgeons to better assess the factors impacting patient outcomes

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Impella CP pump shows survival benefit in cardiogenic shock

Study provides insights on lung transplantation in advanced age candidates

Interatrial shunt may offer differential benefits based on heart failure type

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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