Triple Negative Breast Cancer News and Research

RSS

Cancer cell vulnerability could be a potential target for interrupting tumor growth

Unraveling the unique characteristics of cancer cells and finding less-harmful ways to stop their growth have long been a focus for cancer researchers worldwide.

22 Feb 2021

Tiny molecular motions are of key significance in modern anti-cancer drugs

Modern immunotherapeutic anti-cancer drugs support a natural mechanism of the immune system to inhibit the growth of cancer cells.

3 Feb 2021

IU researchers identify how breast cancer cells evade immune attacks

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified how breast cancer cells hide from immune cells to stay alive. The discovery could lead to better immunotherapy treatment for patients.

27 Jan 2021

Targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.

15 Jan 2021

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer's aggressiveness.

28 Dec 2020

UVA researchers discover gene responsible for the metastasis of triple-negative breast cancer

University of Virginia Cancer Center researchers have identified a gene responsible for the spread of triple-negative breast cancer to other parts of the body - a process called metastasis - and developed a potential way to stop it.

20 Nov 2020

Inflammasome may play a key role in triggering immune response to cancer

The inflammasome — a protein signaling network that is activated to rid the body of virus or bacteria-infected cells — may play an important role in triggering an immune response to cancer and causing an existing class of drugs to work better against cancers.

27 Oct 2020

Researchers recommend breast cancer screening for Black women aged 40 or below

Though Black women get breast cancer at a 3% lower incidence rate than white women, they are 42% more likely to die of breast cancer than white women.

27 Oct 2020

ACGT awards $500,000 grant to advance strategies for treating solid tumors

With a $500,000 Research Grant from Alliance for Cancer Gene Therapy, Sidi Chen, PhD, assistant professor in the Department of Genetics and Systems Biology Institute at Yale School of Medicine and member of Yale Cancer Center, will advance a versatile and highly scalable strategy he's been developing and calling MAEGI -- Multiplexed Activation of Endogenous Genes as an Immunotherapy.

6 Oct 2020

Researchers receive NCI grant to study role of collagens in breast cancer

An MUSC Hollings Cancer Center researcher received a $3 million grant from the National Cancer Institute to study how patterns of collagens can serve as biomarkers of breast cancer risk and potentially reveal clues to what might be driving health disparities.

1 Oct 2020

Researchers develop 'Trojan horse' approach to destroy cancer cells

Cancer cells are killed in lab experiments and tumour growth reduced in mice, using a new approach that turns a nanoparticle into a 'Trojan horse' that causes cancer cells to self-destruct, a research team at the Nanyang Technological University, Singapore (NTU Singapore) has found.

23 Sep 2020

Developing more precise, targeted therapy for a highly aggressive breast cancer

Taking advantage of a cancer cell's altered metabolism that drives its runaway growth, Princess Margaret researchers are zeroing in on these molecular changes to help them develop more precise drug targets for one of the most deadly breast cancers.

21 Aug 2020

Key molecule can be used to assess prognosis of triple negative breast cancer

Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.

21 Aug 2020

New type of immunotherapy extends survival of mice with triple negative breast tumors

Immunotherapies for cancer -; treatments that prime the immune system to attack tumors -; are valuable weapons in the anti-cancer arsenal. But some cancers are more difficult to target with this strategy than others.

17 Aug 2020

Eikonoklastes Therapeutics announces closing of oversubscribed seed financing

Eikonoklastes Therapeutics, a preclinical stage biopharmaceutical company developing next-generation tissue factor (TF) immunotherapies for triple-negative breast cancer (TNBC) and several other diseases with unmet clinical need, today announced closing of an oversubscribed seed financing.

23 Jul 2020

Study finds viable drug target for triple negative breast cancer

One member of a larger family of oxygen sensing enzymes could offer a viable target for triple negative breast cancer (TNBC), UTSW researchers report in a new study.

23 Jul 2020

Researchers develop new nano drug that kills triple-negative breast cancer cells

Researchers at the University of Arkansas have developed a new nano drug candidate that kills triple negative breast cancer cells.

20 Jul 2020

Upcoming phase II study to discover personalized therapy for patients at high risk for breast cancer relapse

Indiana University School of Medicine researchers Milan Radovich, PhD, and Bryan Schneider, MD, have discovered that the presence of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) in the plasma of women's blood who have undergone chemotherapy prior to surgery for the treatment of stage 1, 2 or 3 triple negative breast cancer are critical indicators for the prediction of disease recurrence and disease-free survival.

10 Jul 2020

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that IQGAP1 is a signaling scaffold implicated in TNBC, but its mechanism is unknown.

30 Jun 2020

Researchers examine the role of two genes that cause triple-negative breast cancer

Researchers at Tulane University School of Medicine identified a gene that causes an aggressive form of breast cancer to rapidly grow.

3 Jun 2020