Tumor Associated Macrophages News and Research

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Study shows how radiotherapy alters the behavior of immune cells in glioblastoma tumors

A Ludwig Cancer Research study has dissected how radiotherapy alters the behavior of immune cells known as macrophages found in glioblastoma (GBM) tumors and shown how these cells might be reprogrammed with an existing drug to suppress the invariable recurrence of the aggressive brain cancer.

16 Jul 2020

Researchers reveal novel player in obesity-related breast cancer

It is widely accepted that higher levels of body fat increase the risk of developing breast cancer, as well as other cancers.

13 Apr 2020

New molecular mechanism that regulates the sentinel cells of the immune system

A study suggests that it may be possible to regulate macrophages with drugs that modulate the nuclear receptor RXR.

3 Apr 2020

Targeting the microenvironment of cancer cells to inhibit tumor growth

The recognition of bacterial infections or foreign substances is mediated and controlled by the human immune system. This innate and adaptive immune system comprises the most important metabolic and cellulare processes to fight against infections and other diseases.

5 Feb 2020

New target protein linked to regulation, movement of tumor-associated macrophages

Developing a therapy to combat cancer remains one of the most difficult challenges in medical research. Cancer owes its notorious identity to the fact that the cancer cells use the host's own immune system to grow and spread, ultimately becoming deadly.

30 Jan 2020

Pathios appoints Stuart Hughes as CEO and announces US$8.8M Series A financing round

Pathios Therapeutics Limited, an innovative biotech company focused on the development of first-in-class therapies for autoimmune diseases and cancer, today announced a US$8.8M Series A financing round with leading international healthcare investors Canaan and Australia’s Medical Research Commercialization Fund managed by Brandon Capital.

9 Jan 2020

Novel method for aggressive breast cancer detection

A new study in rats published in the journal Cell Reports shows that the pattern of RNA molecules produced within certain immune cells called macrophages, found within breast cancers (tumor-associated macrophages, TAMs), can tell whether the tumor is cancerous or not and indicate the type of outcome. The same pattern is present in humans as in mice. This makes it directly useful in predicting the nature of a breast tumor and its outcome.

30 Oct 2019

Discovery reveals why newer PD-1 targeted therapies sometimes fail

Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute report a discovery that helps scientists understand why some tumors lack immune cell infiltration and are therefore unresponsive to newer PD-1 targeted therapies.

23 Oct 2019

Novel immunotherapy method could overcome tumor immunity

Cancer immunotherapy is a form of treatment in which the body’s own immune cells are recruited to overcome the tumor. However, it is only useful in a few tumors, because of tumor immunity where tumor-associated immune cells work to protect the tumor against attack.

28 Aug 2019

UC San Diego researchers identify new therapeutic approach to kill cancer cells

Epithelial cancers, such as cancers of the lung and pancreas, use the ανβ3 molecule to gain drug resistance to standard cancer therapies and to become highly metastatic.

22 Aug 2019

Study reveals how aggressive prostate cancer metastasizes by evading the immune system

Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the the immune system.

18 Jul 2019

Findings suggest new ways to help the immune system fight pancreatic cancer

Findings published today in the journal Science Translational Medicine suggest that a type of white blood cell called tumor associated macrophages that have been deceived by pancreatic cancer cells into not attacking them can be "re-programmed" by a specially designed molecule that activates a protein found on their surfaces.

4 Jul 2019

New resistance mechanism that prevent formation of blood vessels

Researchers at IDIBELL-ICO describe a new resistance mechanism to therapies that prevent the formation of blood vessels

3 Jul 2019

Scientists use advanced imaging to track brain tumor 'turncoats'

Glioblastomas, the deadliest type of brain tumor in adults, attract "turncoats." These are macrophages, a type of immune cell, which promote tumor progression and mask tumors from the immune system's scrutiny.

26 Jun 2019

Novel agent shown to have dual mechanism of action to eliminate cancer

Results from a study spearhead by researchers at the Vall d´Hebron Institute of Oncology (VHIO), show that the blockade of the multi-functional cytokine LIF induces tumor-infiltrating T Cells to hone in on and eliminate cancer.

11 Jun 2019

Researchers identify macrophages' pathway to nurture PTEN-deficient glioblastoma

A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Cell.

11 Jun 2019

Precise decoding of breast cancer cells paves way for new treatment option

Researchers at the University of Zurich and from IBM Research have investigated the varying composition of cancer and immune cells in over one hundred breast tumors.

16 Apr 2019

Immune cells key to predicting outcomes in cancer patients, study suggests

Scientists have identified key changes in immune cells within cancerous tumors that could help improve the development of treatments.

8 Apr 2019

Tumor-associated macrophages block activity of chemotherapy drug in pancreatic cancer

A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug's action, research led by the University of Michigan Rogel Cancer Center found.

27 Mar 2019

Immunotherapeutic antibody therapy to kill cancer has now progressed to patient testing

Developed by researchers at the University of Turku in Finland, an immunotherapeutic antibody therapy re-educates macrophages to activate passivated cytotoxic T cells to kill cancer. The antibody therapy prevented the growth of tumors in several mouse models.

20 Feb 2019