Tumorigenesis News and Research

RSS

Tumorigenesis is the process involved in the production of a new tumor or tumors.

Cyclin D1 protein controls cell cycle progression, microRNA biogenesis in breast cancer

Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research publishing November 29 in Nature Communications. The research suggests that a protein strongly implicated in human cancer also governs the non-protein-coding genome. The non-coding genome, previously referred to as junk DNA, makes up most of the human genome, and unlike the coding genome, varies greatly between species.

29 Nov 2013

Study suggests that therapies targeting KDM2A may benefit subset of NSCLS patients

Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer deaths worldwide. Current therapies that target cellular kinases have been effective for some patients: however, many individuals with NSCLS do not respond.

11 Nov 2013

Researchers discover relationship between TGFb signalling pathways and CXCR4 in HCC

Researchers from the Biological clues of the invasive and metastatic phenotype group of the Bellvitge Biomedical Research Institute (IDIBELL) led by Isabel Fabregat have discovered the relationship between the TGFb signalling pathways and CXCR4 in hepatocellular carcinoma (HCC) .

7 Nov 2013

Study: Interactions between inflammation and changes in gut microbiota may result in colon tumors

Transferring the gut microbes from a mouse with colon tumors to germ-free mice makes those mice prone to getting tumors as well, according to the results of a study published in mBio-, the online open-access journal of the American Society for Microbiology.

6 Nov 2013

Toxicity limits benefits of bevacizumab–erlotinib NSCLC maintenance therapy

Two targeted anticancer drugs used together after first-line chemotherapy for advanced stage non-small-cell lung cancer improve progression-free survival, the results of a large, prospective study show.

31 Oct 2013

Verastem presents positive results from VS-6063 clinical and preclinical studies at 2013 AACR-NCI-EORTC meeting

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced positive results from the Phase 1 portion of its Phase 1/1b study of defactinib (VS-6063) in combination with paclitaxel in patients with ovarian cancer that were presented at the 2013 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

21 Oct 2013

High levels of HDL have been linked to increased breast cancer risks, enhance cancer aggressiveness

High levels of high density lipoprotein (HDL), also known as the "good cholesterol," are thought to protect against heart disease. However, what's good for one disease may not be good for another.

10 Oct 2013

c-Fos oncogene cab be important target for understanding and treatment of cancer

The c-Fos oncogene has traditionally been linked to cellular activities related to cancer, such as cell division, differentiation-conversion from one cell type to another-or survival. Any alteration of these activities can set off the development of tumours, which has made c-Fos an important target for the understanding and treatment of cancer.

29 Sep 2013

TSRI scientists discover isoform of angiomotin protein responsible for tumorigenesis

A team led by scientists from The Scripps Research Institute (TSRI) have shown that a protein once thought to inhibit the growth of tumors is instead required for initial tumor growth. The findings could point to a new approach to cancer treatment.

5 Sep 2013

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Mitosis is the process by which a cell gives rise to two daughter cells. It’s the basis behind the growth of the human body, the renewal of the human body as it ages, and unfortunately, the growth of cancers.

7 Aug 2013

Largest data set of cancer-specific genetic variations generated by NCI scientists

Scientists at the National Cancer Institute have generated a data set of cancer-specific genetic variations and are making these data available to the research community, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

16 Jul 2013

CUMC researchers develop new approach to tailor cancer therapy for individual patient

Columbia University Medical Center (CUMC) researchers are developing a new approach to cancer clinical trials, in which therapies are designed and tested one patient at a time.

16 Jul 2013

Scientists focus on the role of mutated adult neural stem cells play in human diseases

CHARGE syndrome* is a severe developmental disorder affecting multiple organs. It affects 1 in 8500 newborns worldwide. The majority of patients carry a mutation in a gene called CHD7. How this single mutation leads to the broad spectrum of characteristic CHARGE symptoms has been a mystery.

6 Jul 2013

Researchers find NRF2 signaling plays a role in growth of tumor cells by altering metabolic pathways

Cancer cells have alteration in metabolic pathways as a result of oncogenes that promote tumor growth. NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a "master gene" that turns on stress response by increasing numerous antioxidants and pollutant-detoxifying genes to protect the lungs from variety of air pollutants such as diesel exhaust and cigarette smoke.

3 Jul 2013

Researchers develop new drug delivery systems to treat cancer by blocking signaling receptor

A cardiac hormone signaling receptor abundantly expressed both in inflamed tissues and cancers appears to recruit stem cells that form the blood vessels needed to feed tumor growth, reports a new study by scientists at the University of South Florida Nanomedicine Research Center.

30 Jun 2013

Tumorigenesis News and Research

Cyclin D1 protein controls cell cycle progression, microRNA biogenesis in breast cancer

Study suggests that therapies targeting KDM2A may benefit subset of NSCLS patients

Researchers discover relationship between TGFb signalling pathways and CXCR4 in HCC

Study: Interactions between inflammation and changes in gut microbiota may result in colon tumors

Toxicity limits benefits of bevacizumab–erlotinib NSCLC maintenance therapy

Verastem presents positive results from VS-6063 clinical and preclinical studies at 2013 AACR-NCI-EORTC meeting

High levels of HDL have been linked to increased breast cancer risks, enhance cancer aggressiveness

c-Fos oncogene cab be important target for understanding and treatment of cancer

TSRI scientists discover isoform of angiomotin protein responsible for tumorigenesis

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Largest data set of cancer-specific genetic variations generated by NCI scientists

CUMC researchers develop new approach to tailor cancer therapy for individual patient

Scientists focus on the role of mutated adult neural stem cells play in human diseases

Researchers find NRF2 signaling plays a role in growth of tumor cells by altering metabolic pathways

Researchers develop new drug delivery systems to treat cancer by blocking signaling receptor

Decorin protein in blood inhibits tumor progression, say researchers

Tumor suppressor p53 inactivation and restoration: an interview with Dr. Xin Lu, Ludwig Institute for Cancer Research

The Biology of Cancer: New second edition now available

New study identifies four genetic variants associated with increased risk of testicular cancer

Scientists halt tumour development through genetic manipulation of cytoskeleton in fly tissues

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Latest News