Tumorigenesis is the process involved in the production of a new tumor or tumors.
Dr. Anthony E. Oro and colleagues (Stanford University) have identified two key Gli protein degradation signals that directly affect tumor latency in a mouse model of human skin cancer.
A collaboration of researchers, led by Dr. Martine Roussel of St. Jude Children's Research Hospital, has developed a novel mouse model of medulloblastoma -- the most prevalent malignant pediatric brain tumor -- that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.
Most investigations into cancer have focused on chemical signals, but a new research study provides rare insight into how mechanical force can regulate cellular behavior.
Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2.
Curcumin, a spice commonly used in curries and other south Asian cooking, blocks a key biological pathway needed for development of melanoma and other cancers, say researchers from the University of Texas M. D. Anderson Cancer Center.
Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung.
The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb.
Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors.
These parity-induced mammary epithelial cells (PI-MEC) have the ability to self-renew over many generations and to differentiate into numerous cellular subtypes.
Researchers at the Uppsala Branch of the Ludwig Institute for Cancer Research have discovered that the transcription factor Yin Yang 1 (YY1) is a novel regulator of the tumor suppressor p53, which is inactivated in at least half of all human cancers.