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Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

A recent review in the journal Immunity delves into the crucial role of dendritic cells (DCs) in shaping T-cell responses in cancer, highlighting their importance in both priming anti-tumor immunity and in ongoing immune interactions within tumors. The findings underscore the potential of DCs as key targets for next-generation cancer immunotherapies.

18 Sep 2023

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

Researchers designed and evaluated a multi-epitope vaccine targeting the main outer membrane protein of Chlamydia pneumoniae using immunoinformatics.

14 Sep 2023

A combination of inhibitors may suppress tumor growth and prevent cancer relapse

An international team of researchers has demonstrated that a combination of inhibitors may suppress tumor growth and prevent relapse in patients with certain cancers, including head and neck squamous cell carcinoma and lung adenocarcinoma.

12 Sep 2023

Study provides new hope for patients with stage III EGFR-mutant non-small cell lung cancer

The immunotherapy drug, durvalumab, has been the standard of care for patients with stage III non-small cell lung cancer(NSCLC) to improve survival, when prescribed after chemotherapy and radiation therapy.

11 Sep 2023

Can SARS-CoV-2 infect poultry?

New research in the Virology Journal suggests that chickens could become intermediate hosts for newly emerged SARS-CoV-2 variants, posing a potential threat to public health. The study identifies AXL and ACE2 receptors in chickens as likely binding sites for the virus, highlighting the need for further research and preventive measures.

5 Sep 2023

Combination of cediranib and lenalidomide does not improve outcomes in advanced thyroid cancer

Results of a multicenter phase II clinical trial led by the University of Chicago Medicine Comprehensive Cancer Center show that adding an immunomodulatory agent to treatment with the targeted tyrosine kinase inhibitor (TKI) cediranib did not make a difference in outcomes for treating patients with an advanced form of thyroid cancer that develops from thyroid follicular cells called differentiated thyroid cancer (DTC).

1 Sep 2023

The interplay between immunity, the nervous system, and microbiota

Researchers review the influence of the gut microbiota on neural and immune network

15 Aug 2023

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Researchers used genetically modified animal models to investigate the role of the newly discovered Traf2- and NCK-interacting protein kinase (TNIK) in obesity and metabolic dysfunction.

15 Aug 2023

A computational model identifies metabolites associated with Parkinson's disease

Researchers identify significant metabolites involved in the development and progression of Parkinson’s disease.

15 Aug 2023

CRISPR/sgRNA-SAM therapy: a potential breakthrough for Parkinson's disease?

Researchers utilize the CRISPR-Cas9 system to induce the synthesis of dopamine (DA) in the brains of a rat model for Parkinson’s disease.

11 Aug 2023

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication.

10 Aug 2023

Childhood abuse can induce stress that changes neural networks and functions during growth

Childhood neglect and/or abuse can induce extreme stress that significantly changes neural networks and functions during growth. This can lead to mental illnesses, including depression and schizophrenia, but the exact mechanism and means to control it were yet to be discovered.

4 Aug 2023

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Researchers examined current evidence on the reasons and implications of pancreatic beta-cell failure.

3 Aug 2023

Point-of-care rapid diagnostics for detecting SARS-CoV-2 in exhaled breath

Researchers developed a rapid, non-invasive, point-of-care platform for the direct detection of SARS-CoV-2 in exhaled breath.

3 Aug 2023

Penn Medicine and CHOP receive $26 million NIH grant to develop treatments for three rare genetic diseases

A Penn Medicine and Children's Hospital of Philadelphia (CHOP) team will seek to develop treatments for three rare, incurable genetic diseases with the help of a $26 million grant from the National Institutes of Health (NIH).

1 Aug 2023

Study shows that anti-PTM antibodies are often present in autoimmune mediated liver disease

A recent study published in Frontiers in Medicine described anti-post-translational modification (PTM) antibodies in patients with autoimmune-mediated and cholestatic liver diseases (AILD).

31 Jul 2023

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Study aimed to understand the specific needs of lung cancer in never smokers (LCINS) patients.

25 Jul 2023

New sensor may be deployed to screen patients for hard-to-diagnose cancers

Drawing inspiration from natural sensory systems, an MIT-led team has designed a novel sensor that could detect the same molecules that naturally occurring cell receptors can identify.

21 Jul 2023

BUB1 protein and its kinase activity may regulate EGFR activation

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, "Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization."

18 Jul 2023

New study reveals how lung tumors develop drug resistance

Cancer therapies that target specific genetic abnormalities in tumors have revolutionized treatment possibilities over the past two decades.

13 Jul 2023

Tyrosine News and Research

Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

A combination of inhibitors may suppress tumor growth and prevent cancer relapse

Study provides new hope for patients with stage III EGFR-mutant non-small cell lung cancer

Can SARS-CoV-2 infect poultry?

Combination of cediranib and lenalidomide does not improve outcomes in advanced thyroid cancer

The interplay between immunity, the nervous system, and microbiota

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

A computational model identifies metabolites associated with Parkinson's disease

CRISPR/sgRNA-SAM therapy: a potential breakthrough for Parkinson's disease?

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Childhood abuse can induce stress that changes neural networks and functions during growth

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Point-of-care rapid diagnostics for detecting SARS-CoV-2 in exhaled breath

Penn Medicine and CHOP receive $26 million NIH grant to develop treatments for three rare genetic diseases

Study shows that anti-PTM antibodies are often present in autoimmune mediated liver disease

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

New sensor may be deployed to screen patients for hard-to-diagnose cancers

BUB1 protein and its kinase activity may regulate EGFR activation

New study reveals how lung tumors develop drug resistance

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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