VEGF News and Research

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VEGF is a substance made by cells that stimulates new blood vessel formation. Also called vascular endothelial growth factor.

Clockwork in cancer: the importance of the circadian rhythm in the formation and progression of tumors

Researchers reviewed the importance of the circadian rhythm in the formation and progression of tumors.

29 Mar 2023

Study sheds new insight into the dynamics of neural stem cell niche

When it comes to cell types, stem cells have unlimited potential – literally. These self-renewing cells, which are capable of giving rise to any cell type in the body, reside in specialized microenvironments known as niches.

16 Mar 2023

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

A type of immune therapy called chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of multiple types of blood cancers but has shown limited efficacy against glioblastoma-;the deadliest type of primary brain cancer-;and other solid tumors.

14 Mar 2023

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

Researchers assessed the impact of an anti-CD3 monoclonal antibody called Foralumab in COVID-19 treatment.

9 Mar 2023

UVA research provides new insight into common causes of vision loss

UVA Health scientists have discovered an unknown contributor to harmful blood vessel growth in the eye that could lead to new treatments for blinding macular degeneration and other common causes of vision loss.

24 Feb 2023

Study investigates anti-VEGF treatment for inflammatory eye disease in HTLV-1–infected ocular cells

A retrovirus known as human T-cell lymphotropic virus type 1 (HTLV-1) is known to cause a number of diseases, including inflammatory diseases of the eye. Recently, researchers in Japan have investigated an antibody treatment for inflammatory eye disease in ocular cells infected with HTLV-1.

21 Feb 2023

Penn engineers address the longstanding gap in reproductive health care with targeted RNA therapy

Pre-eclampsia is a leading cause of stillbirths and prematurity worldwide, occurring in 3 – 8 % of pregnancies. A disorder characterized by high maternal blood pressure, it results from insufficient vasodilation in the placenta, restricting blood flow from the mother to the fetus.

16 Feb 2023

Study shows activation of pulmonary macrophages by SARS-CoV-2 spike glycoprotein

In a recent study published in the International Journal of Molecular Sciences, researchers investigated the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein on human lung macrophage (HLM) activation and angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) expression in human lung macrophages.

7 Feb 2023

Early treatment of diabetes-related eye disease does not improve visual acuity

While early treatment of diabetes-related eye disease slowed progression to severe disease, it did not improve visual acuity compared with treating more severe disease once it developed, according to a clinical study from the DRCR Retina Network.

7 Feb 2023

Recent therapeutic strategies for renal cell carcinoma and the effects of the tumor microenvironment on systemic therapy

Researchers explored the association between the human microbiome and improved renal cell carcinoma outcomes.

6 Feb 2023

Study identifies a drug candidate for the treatment of fatty liver disease

There is currently no drug for treating non-alcoholic fatty liver disease, which affects many people with type 2 diabetes and which can result in other serious liver diseases.

3 Feb 2023

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia (AML) patients with a mutant Ikaros zinc finger protein 1 (IKZF1).

2 Feb 2023

Study reveals why hypoglycemic episodes worsen diabetic retinopathy

People with diabetes who experience periods of low blood sugar — a common occurrence in those new to blood sugar management — are more likely to have worsening diabetic eye disease.

26 Jan 2023

Sex-specific patterns of cytokine activation in the hippocampus post-immunological challenge

Researchers evaluated sex-based differences among cytokine and chemokine networks in the hippocampus after systemic immunological challenge.

25 Jan 2023

How does the brain change with age?

Researchers discussed cellular hallmarks of brain aging and therapeutic interventions to rejuvenate cognitive brain functions.

19 Jan 2023

What are the effects of prenatal exposure to alcohol and marijuana on fetal development?

Researchers presented the effects of simultaneous alcohol and cannabinoid (SAC) usage during gestation on fetal brain development.

10 Jan 2023

Mediterranean diet may benefit health in part by incorporating moderate wine consumption

Many public health warnings have been issued against alcohol consumption, even in small quantities, though the evidence for such strict limits is controversial. The current study, published in the MDPI journal Nutrients, is a narrative review focused on clearing up some of the confusion associated with alcoholic drinks.

4 Jan 2023

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