VEGF News and Research

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VEGF is a substance made by cells that stimulates new blood vessel formation. Also called vascular endothelial growth factor.

Researchers identify new targets to control angiogenesis

Angiogenesis is a process of new vessel formation that is activated both in physiological (tissue repair, reproduction, etc.) and pathological (myocardial infarction, diabetic retinopathy, cancer, etc.) conditions.

16 Apr 2021

Early treatment with anti-VEGF injections slows diabetic retinopathy

Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.

31 Mar 2021

New therapeutic vaccine uses patient's own tumor cells to aid in cancer destruction

Immunotherapy, which recruits the body's own immune system to attack cancer, has given many cancer patients a new avenue to treat the disease.

24 Mar 2021

New study sheds light on cancer metastasis

Breast cancer is harmful enough on its own, but when cancer cells start to metastasize -- or spread into the body from their original location -- the disease becomes even more fatal and difficult to treat.

12 Mar 2021

Studies reveal how kidney tumors' microenvironments change in response to immunotherapy

In the last two decades, immunotherapy has emerged as a leading treatment for advanced renal carcinoma cancer (more commonly known as kidney cancer).

11 Mar 2021

Scientists find new therapeutic approach to effectively treat age-related macular degeneration

Runt-related transcription factor 1 (RUNX1) has been linked to retinal neovascularization and the development of abnormal blood vessels, which result in vision loss in diabetic retinopathy.

22 Feb 2021

Study profiles the nose to predict immune response during COVID-19

SARS-CoV-2 resides in mucous membranes, making it easy to detect viral load in the nasal cavities. An international group of researchers has characterized the immunological and diagnosis characteristics of patients who may have or are confirmed with SARS-CoV-2 infection. The team found a distinct nasal cytokine profile that could help identify patients at risk for high inflammatory responses to SARS-CoV-2 infection.

22 Feb 2021

Targeted drug combined with immunotherapy prolongs survival in patients with advanced kidney cancer

Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

13 Feb 2021

Researchers analyze overall survival rate of prostate cancer patients treated with melatonin

Oncotarget recently published "Melatonin increases overall survival of prostate cancer patients with poor prognosis after combined hormone radiation treatment" which reported that a retrospective study included 955 patients of various stages of prostate cancer who received combined hormone radiation treatment from 2000 to 2019.

11 Feb 2021

Anticancer drug may reduce mortality and speed up recovery for severe COVID-19 patients

Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020.

6 Feb 2021

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

Hypoxia -- where a tissue is deprived of an adequate supply of oxygen -- is a feature inside solid cancer tumors that renders them highly invasive and resistant to treatment. Study of how cells adapt to this critical stressor, by altering their metabolism to survive in a low-oxygen environment, is important to better understand tumor growth and spread.

4 Feb 2021

Combining PD-1 and VEGF inhibitors with chemotherapy can help control cholangiocarcinoma

Cholangiocarcinoma (CCA) is considered as a diverse group of epithelial cancers characterized by poor outcomes. Cholangiocarcinoma can be divided into three types according to the original position: Intrahepatic Cholangiocarcinoma (ICC), Perihilar Cholangiocarcinoma (PCC), and Distal Extrahepatic Tumors (DET).

3 Feb 2021

ACE2 and furin levels linked to inflammation in smokers with COVID-19

A new study reports the level of ACE2 and furin, two enzymes that are intimately linked to infection with SARS-CoV-2, the causative agent of COVID-19.

21 Jan 2021

Potentially promising therapeutic combination for renal cell carcinoma uncovered

Renal cell carcinoma (RCC) is the most common form of cancer of the kidney. In 2018, there were an estimated 403,000 new cases of RCC and 175,000 deaths due to kidney cancer worldwide.

20 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Researchers identify adenovirus gene therapy for placental insufficiency

A new study identified an adenovirus gene therapy vector carrying a VEGF isoform. It can improve uterine blood flow in placental insufficiency, as reported in the peer-reviewed journal Human Gene Therapy.

15 Dec 2020

Surgical and drug treatment approaches are equally effective for diabetic eye disease

Surgical and injectable drug approaches are equally effective for treatment of bleeding inside the eye from proliferative diabetic retinopathy (PDR), according to a National Eye Institute (NEI)-supported clinical study from the DRCR Retina Network (DRCR.net).

15 Dec 2020

Unique inhibitory protein may suppress the formation of cancer cells

Researchers from Tokyo Medical and Dental University (TMDU) identify a novel role for a protein, vasohibin-1, in preventing cancer cells from spreading

15 Dec 2020

Findings about primary cilia may be relevant for transplantation therapies in diabetes

A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets.

5 Dec 2020

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

In an article published in the journal Virus Research, a team of researchers from various US institutions discussed their study that evaluated the antiviral activity of PTC299 against a group of RNA viruses in vitro.

1 Dec 2020

VEGF News and Research

Further Reading

Researchers identify new targets to control angiogenesis

Early treatment with anti-VEGF injections slows diabetic retinopathy

New therapeutic vaccine uses patient's own tumor cells to aid in cancer destruction

New study sheds light on cancer metastasis

Studies reveal how kidney tumors' microenvironments change in response to immunotherapy

Scientists find new therapeutic approach to effectively treat age-related macular degeneration

Study profiles the nose to predict immune response during COVID-19

Targeted drug combined with immunotherapy prolongs survival in patients with advanced kidney cancer

Researchers analyze overall survival rate of prostate cancer patients treated with melatonin

Anticancer drug may reduce mortality and speed up recovery for severe COVID-19 patients

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

Combining PD-1 and VEGF inhibitors with chemotherapy can help control cholangiocarcinoma

ACE2 and furin levels linked to inflammation in smokers with COVID-19

Potentially promising therapeutic combination for renal cell carcinoma uncovered

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Researchers identify adenovirus gene therapy for placental insufficiency

Surgical and drug treatment approaches are equally effective for diabetic eye disease

Unique inhibitory protein may suppress the formation of cancer cells

Findings about primary cilia may be relevant for transplantation therapies in diabetes

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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