Wilms Tumor News and Research

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Wilms Tumor is a disease in which malignant (cancer) cells are found in the kidney, and may spread to the lungs, liver, or nearby lymph nodes. Wilms tumor usually occurs in children younger than 5 years old.

New kidney tissue model could help assess safety of immunotherapy drugs

A growing repertoire of cell and molecule-based immunotherapies is offering patients with indomitable cancers new hope by mobilizing their immune systems against tumor cells.

23 Aug 2023

Research provides insight into genetic mechanisms of Wilms tumor

New research from Ann & Robert H. Lurie Children's Hospital of Chicago and collaborators from other institutions provides insights into some of the genetic characteristics resulting in the development of relapse in patients with Wilms tumor (nephroblastoma), the most common type of pediatric cancer of the kidney.

24 May 2022

Study finds higher risk of all-cause mortality among pediatric cancer patients in LMICs during the pandemic

During the first nine months of the COVID-19 pandemic, pediatric cancer patients from lower- and middle-income countries faced a higher risk of all-cause mortality than those in high-income countries, according to data presented at the AACR Annual Meeting 2022, held April 8-13.

11 Apr 2022

Scientists publish the most extensive description to date of WAGR syndrome

Researchers from Children's Hospital of Philadelphia (CHOP) have published the most comprehensive description to date of the rare genetic disorder known as WAGR syndrome. This new report identified several clinical issues not classically associated with the disease and provides guidance for proper diagnosis, management, and potential treatment options.

21 Dec 2021

RENAL nephrometry score may help predict which patients are suitable for nephron-sparing surgery

For most children with renal masses, the standard of care has long been to remove the entire affected kidney- which is the protocol for Wilms tumor, the most common kidney cancer in children.

6 Dec 2021

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

29 Sep 2021

Cognitive outcomes in survivors of childhood cancers have been largely understudied

In a new study led by Yale Cancer Center, researchers report many survivors of childhood cancers receive systemic therapies associated with cognitive effects and chronic health conditions that may impact long-term cognitive outcomes with downstream effects on education, employment, and income.

23 Apr 2021

Powerful treatment for IPF stops dangerous scar formation in mouse lungs

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

6 Aug 2020

Study opens up new treatment possibilities for Wilms' tumor

As an embryo develops, its cells must learn what to do with the thousands of genes they've been equipped with. That's why each cell comes with a detailed gene-expression manual outlining exactly which genes should be switched on, to what extent, and when.

18 Dec 2019

St. Jude Children's Research Hospital and IAEA team up to combat childhood cancers

The International Atomic Energy Agency and St. Jude Children's Research Hospital are joining forces to combat childhood cancers in developing countries, where children are four times more likely to die of the disease than in high-income countries due to a lack of affordable treatment and quality care options.

18 Oct 2019

'Kidney-gene' plays role in the central nervous system and controls movement

The WT1 gene fulfills a central role in the development of a healthy, proper functioning kidney. Mutations in WT1 lead to impairments in kidney development and cause Wilms tumors, a pediatric kidney cancer.

1 Oct 2018

Study reveals how socioeconomic status affects racial, ethnic disparities in childhood cancer survival

A new study provides insights into the degree to which socioeconomic status explains racial and ethnic disparities in childhood cancer survival.

20 Aug 2018

New CAR T-cell immunotherapy trial targets solid tumors

Seattle Children's has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.

7 Aug 2018

Researchers uncover new mechanisms underlying common kidney cancer in children

Connecting two previously unrelated insights about the formation of pediatric kidney cancer, researchers at UT Southwestern Medical Center have uncovered the means by which the cancer continues to grow, providing potential targets for more effective treatments in the future.

2 Aug 2018

Scientists discover genetic causes underlying group of related infant cancers

The genetic causes of a group of related infant cancers have been discovered by scientists at the Wellcome Sanger Institute, the University of Wuerzburg and their collaborators.

18 Jun 2018

Study shows four survival strategies of tumor cells in childhood cancer

Cancer cells in children tend to develop by following four main trajectories - and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows.

5 Jun 2018

Study shows new approach to improve survival rates for patients with stage IV Wilms tumors

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology.

26 Apr 2018

TSRI scientists find new approach to reprogram ordinary adult cells into IPSCs

Scientists at The Scripps Research Institute have found a new approach to the "reprogramming" of ordinary adult cells into stem cells.

12 Sep 2017

St. Jude creates world’s largest collection of pediatric solid tumor samples

In an effort to improve outcomes for patients with some of the deadliest childhood cancers, St. Jude Children's Research Hospital scientists have created the world's largest collection of pediatric solid tumor samples, drug-sensitivity data and related information and have made the resource available at no charge to the global scientific community.

31 Aug 2017

Early death from pediatric cancer subtypes more likely to happen than previously reported

Treatments for childhood cancers have improved to the point that 5-year survival rates are over 80 percent. However, one group has failed to benefit from these improvements, namely children who die so soon after diagnosis that they are not able to receive treatment, or who receive treatment so late in the course of their disease that it is destined to fail.

8 Mar 2017