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New understanding of chromosomal glue

Researchers have a new understanding of the process cells use to ensure that sperm and eggs begin life with exactly one copy of each chromosome - a process that must be exquisitely regulated to prevent problems such as miscarriages and mental retardation.

8 May 2006

New approaches to genetic disease, based on cells' own ability to correct themselves

New approaches to genetic disease, based on cells' own ability to correct themselves, will be outlined today at the annual conference of the European Society of Human Genetics in Amsterdam, The Netherlands.

8 May 2006

Mutated gene leads to JSRD

The research team, directed by Joseph Gleeson, M.D., Director of the Neurogenetics Laboratory at the UCSD School of Medicine and associate professor in the Department of Neurosciences, have identified a new gene that, when mutated, leads to JSRD. Their findings will be published on-line in advance of publication in the journal Nature Genetics.

8 May 2006

Environmentally damaged DNA may contribute to human genetic diversity

In this month's issue of the leading scientific journal Genome Research, scientists from Kyushu University report how environmentally damaged DNA may contribute to human genetic diversity.

2 May 2006

Finding indicate why some kinds of Leukemia are more aggressive than others

New clues to why some kinds of leukemia are more aggressive and deadly than others are coming from research examining the types of genetic damage that allow some blood cells to grow out of control, scientists report.

28 Apr 2006

Blood cancers may be caused by inactivation of a "tumor suppressor" gene

The discovery of a gene, called PRDM1, as a tumor suppressor sheds new light on the cause - and possible treatment - of diffuse large B-cell lymphomas (DLBCLs), a cancer of the blood's B-lymphocytes. DLBCLs comprise about 30 percent of non-Hodgkin's lymphomas.

25 Apr 2006

Cancer found grow by switching off DNA - may lead to new generation treatments

Cancer researchers have formulated a new concept for how cancer cells can escape normal growth controls by turning off DNA. These findings may have far-reaching implications for the new generation of cancer therapies.

25 Apr 2006

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

23 Apr 2006

New method designed to analyze the genes that regulate the immune system

Seattle scientists have developed a new method for analyzing the Major Histocompatibility Complex (MHC) of the human genome.

20 Apr 2006

Promising treatment for Huntington's disease soon to be tested clinically

At the Institut Curie, CNRS and Inserm researchers have shown that cysteamine, which is already used to treat a rare disease called cystinosis, prevents the death of neurons in Huntington's disease. Like Alzheimer's and Parkinson's, Huntington's disease, is characterized by the abnormal death of neurons.

19 Apr 2006

Researchers develop system for observing nuclear motion

The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around.

18 Apr 2006

First gene therapy human trial in the United States for a form of muscular dystrophy under way

The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina Chapel Hill's School of Medicine and the University of Pittsburgh.

16 Apr 2006

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

A study led by researchers from the Howard Hughes Medical Institute has found that dasatinib provides significant benefit in chronic myeloid leukemia (CML) patients resistant to Gleevec. (imatinib), according to a study presented during the 97th Annual Meeting of the American Association for Cancer Research.

11 Apr 2006

Researchers identify the role of a protein in hemoglobin gene silencing

Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.

11 Apr 2006

Researchers identify new disorder called cortical dysplasia-focal epilepsy syndrome

Researchers from the Translational Genomics Research Institute (TGen) and the Clinic for Special Children (CSC) in Strasburg, PA, have described a new childhood-onset disorder characterized by severe epilepsy and autistic traits, and identified its genetic basis.

11 Apr 2006

Minimal nutritional requirements for growing and maintaining human embryonic stem cells

Researchers at Yale have established the minimal nutritional requirements for growing and maintaining human embryonic stem cells, a recipe that is critical for clinical application and for developmental studies, according to a report in the Proceedings of the National Academy of Sciences.

11 Apr 2006

X chromosome News and Research

New understanding of chromosomal glue

New approaches to genetic disease, based on cells' own ability to correct themselves

Mutated gene leads to JSRD

Environmentally damaged DNA may contribute to human genetic diversity

Finding indicate why some kinds of Leukemia are more aggressive than others

Blood cancers may be caused by inactivation of a "tumor suppressor" gene

Cancer found grow by switching off DNA - may lead to new generation treatments

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

New method designed to analyze the genes that regulate the immune system

Promising treatment for Huntington's disease soon to be tested clinically

Researchers develop system for observing nuclear motion

First gene therapy human trial in the United States for a form of muscular dystrophy under way

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

Researchers identify the role of a protein in hemoglobin gene silencing

Researchers identify new disorder called cortical dysplasia-focal epilepsy syndrome

Minimal nutritional requirements for growing and maintaining human embryonic stem cells

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Weill Cornell experts publish review of genetic medicine

Malaria, mosquitoes and man - breaking a deadly cycle

Weill Cornell researchers identify tumor-suppressor gene important to diffuse large B-cell lymphomas

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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