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New Tel Aviv University study may pave way for personalized bipolar disorder treatment

Rapidly swinging from extremes of joy and energy to sadness, fatigue, and confusion, bipolar disorder (BD) patients feel desperate and largely alone in the world. And according to the National Institutes of Health, between 25-50 percent of the roughly 3% of Americans living with BD attempt suicide at least once.

23 Apr 2015

IMIM researchers identify new way of treating colorectal cancer

Researchers at the Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) have identified a new way of treating colorectal cancer. In the study published in the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated gene.

23 Apr 2015

Botanical formula improves effect of tamoxifen drug in ER+ human breast cancer

Researchers at the Cancer Research Laboratory, Methodist Research Institute, Indiana University Health found that a botanical formula for breast health inhibited the growth of estrogen receptor-positive (ER+) human breast cancer cells. More importantly, the researchers also found that the formula enhanced the anti-cancer benefits of the drug tamoxifen in the treatment of breast cancer.

22 Apr 2015

Honokiol extract holds promise as adjunct treatment for bladder and kidney cancers

The botanical extract honokiol, a biologically active molecule isolated from the bark of Magnolia spp., holds promise as an adjunct treatment for aggressive bladder and kidney cancers, as reported in two new studies. New research on honokiol in bladder cancer was presented at the American Association for Cancer Research Annual Meeting 2015.

22 Apr 2015

Spanish scientists find apatite bioceramics from shark teeth for implants

Researchers from the BIOCAPS Area of 'Biomaterials, tissue engineering and regenerative medicine' have managed to obtain bioceramics from shark teeth, which have already tested applications in the regeneration of bone tissue, particularly in the fields of traumatology and odontology.

22 Apr 2015

Female liver cells become more susceptible to adverse effects of drugs, study finds

Female liver cells, and in particular those in menopaused women, are more susceptible to adverse effects of drugs than their male counterparts, according to new research carried out by the JRC. It is well known that women are more vulnerable when it comes to drug-induced liver effects, but it's the first time it has been shown that there are differences at cellular level.

22 Apr 2015

Rocket carrying Reinnervate's Alvetex Scaffold blasts into Space to find better treatments for bone loss

Market leading 3D cell culture company Reinnervate Ltd, part of the ReproCELL group, today announced that a rocket carrying its Alvetex Scaffold technology blasted into Space this week. Alvetex will be used in experiments on board the International Space Station.

22 Apr 2015

BioReliance inks non-exclusive license agreement with QTS for proprietary B-CLEAR technology

BioReliance, Sigma-Aldrich Corporation's biologics and early-development services business under SAFC Commercial, is pleased to announce a non-exclusive license agreement with Qualyst Transporter Solutions for its proprietary B-CLEAR technology.

21 Apr 2015

Upsher-Smith presents favorable data from PREVAIL OLE study of Qudexy XR capsules

Upsher-Smith Laboratories, Inc. presented data from a 52-week, open-label extension study (PREVAIL OLE) showing that Qudexy XR (topiramate) extended-release capsules offered a long-term adjunctive treatment option with a favorable tolerability profile for a high proportion of patients with refractory partial-onset seizures (POS).

21 Apr 2015

Allele-specific lncRNA regulates cancer metabolism

Long non-coding RNAs (lncRNA) are unusual in that they don't encode proteins like normal RNA. Yet they do play a role in regulating cellular functions and interest cancer researchers.

21 Apr 2015

New combination therapy could overcome treatment resistance, relapse in breast cancer

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer.

21 Apr 2015

Insulin signaling pathway has significant influence on the growth of glioblastomas

Drugs that target insulin pathways to slow or stop the growth of brain tumors are going in the right direction but appear to be on the wrong track, according to new research at Rice University.

21 Apr 2015

Zinc deficiency can activate Hedgehog signaling pathway

Zinc deficiency - long associated with numerous diseases, e.g. autism, lung cancer, prostate cancer, and ovarian cancers - can lead to activation of the Hedgehog signaling pathway, a biomolecular pathway that plays essential roles in developing organisms and in diseases, according to new research at Rensselaer Polytechnic Institute.

17 Apr 2015

Electronic micropump combined with anticonvulsant drug may treat brain diseases

Many potentially efficient drugs have been created to treat neurological disorders, but they cannot be used in practice. Typically, for a condition such as epilepsy, it is essential to act at exactly the right time and place in the brain.

16 Apr 2015

Cepheid, FIND announce receipt of CE-IVD status for Xpert HIV-1 Qual test

Cepheid and FIND today announced that Xpert HIV-1 Qual, a qualitative 90-minute molecular HIV test, has achieved CE-IVD status under the European Directive on In Vitro Diagnostic Medical Devices.

16 Apr 2015

Houston Methodist researchers discover new, ex vivo lung cancer model to study tumor progression

Without good models to study cancer metastasis -- the spread of cancer cells from one organ to another -- cancer researchers have struggled to understand tumor progression fully, and new therapies targeting the main causes of death are slow to come.

16 Apr 2015

Focus Diagnostics announces FDA clearance for Simplexa Group A Strep Direct Kit

Focus Diagnostics, the clinical-laboratory products business of Quest Diagnostics, today announced the FDA 510(k) clearance and CLIA moderate-complexity categorization for its Simplexa Group A Strep Direct Kit. Simplexa Group A Strep Direct is a real-time polymerase chain reaction assay for the detection of Group A Streptococcus bacteria directly from throat swabs.

From Quest Diagnostics 15 Apr 2015

Clyde Biosciences announces £2 million ‘Series A’ investment

Clyde Biosciences Ltd. has announced a £2 million ‘Series A’ investment led by Epidarex Capital, a leading international early-stage life science venture capital fund.

15 Apr 2015

Clyde Biosciences, a leading drug toxicity testing company, closes Series A investment

Clyde Biosciences Ltd. (Clyde Biosciences) has announced a £2 million ‘Series A’ investment led by Epidarex Capital, a leading international early-stage life science venture capital fund. Scottish Enterprise’s investment arm, the Scottish Investment Bank, also participated in the round along with Glasgow University Holdings, Ltd.

14 Apr 2015

LaVision BioTec reports on the Beatson Institute for Cancer Research and their use of multiphoton microscopy to understand the behaviour of cells in cancer metastasis

LaVison BioTec, developers of advanced microscopy solutions for the life sciences, report on the research of Professor Kurt I Anderson and his groups' studies of cell migration in the context of cancer metastasis at the Beatson Institute for Cancer Research...

14 Apr 2015

in vitro News and Research

New Tel Aviv University study may pave way for personalized bipolar disorder treatment

IMIM researchers identify new way of treating colorectal cancer

Botanical formula improves effect of tamoxifen drug in ER+ human breast cancer

Honokiol extract holds promise as adjunct treatment for bladder and kidney cancers

Spanish scientists find apatite bioceramics from shark teeth for implants

Female liver cells become more susceptible to adverse effects of drugs, study finds

Rocket carrying Reinnervate's Alvetex Scaffold blasts into Space to find better treatments for bone loss

BioReliance inks non-exclusive license agreement with QTS for proprietary B-CLEAR technology

Upsher-Smith presents favorable data from PREVAIL OLE study of Qudexy XR capsules

Allele-specific lncRNA regulates cancer metabolism

New combination therapy could overcome treatment resistance, relapse in breast cancer

Insulin signaling pathway has significant influence on the growth of glioblastomas

Zinc deficiency can activate Hedgehog signaling pathway

Electronic micropump combined with anticonvulsant drug may treat brain diseases

Cepheid, FIND announce receipt of CE-IVD status for Xpert HIV-1 Qual test

Houston Methodist researchers discover new, ex vivo lung cancer model to study tumor progression

Focus Diagnostics announces FDA clearance for Simplexa Group A Strep Direct Kit

Clyde Biosciences announces £2 million ‘Series A’ investment

Clyde Biosciences, a leading drug toxicity testing company, closes Series A investment

LaVision BioTec reports on the Beatson Institute for Cancer Research and their use of multiphoton microscopy to understand the behaviour of cells in cancer metastasis

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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