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Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Study suggests new strategy for treating Alzheimer's disease

Alzheimer's disease (AD) is one of the most common form of dementia. In search for new drugs for AD, the research team, led by Professor Mi Hee Lim of Natural Science at UNIST has developed a metal-based substance that works like a pair of genetic scissors to cut out amyloid-β (Aβ), the hallmark protein of AD.

28 Feb 2017

Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

Scientists at the Institute for Infectious Diseases, University of Bern have developed an in vitro stem cell-based bioassay grown on multi-electrode arrays capable of detecting the biological activity of Clostridium botulinum neurotoxins.

28 Feb 2017

SBP researchers identify new regulator of innate immune response to foreign invaders

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a new regulator of the innate immune response—the immediate, natural immune response to foreign invaders.

28 Feb 2017

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

A University of Cincinnati researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says he hopes to have it in clinical trials in human volunteers within a year.

28 Feb 2017

Researchers aim to develop sustained and controllable insulin release system for treatment of diabetes

The prevalence of diabetes has grown around the world over the past three decades. In 2016, the World Health Organization estimated that 422 million people had the disease as the rate of obesity also increased.

27 Feb 2017

Diagnosing Infections Through Molecules in Patient Breath

Over the past couple of decades, the analytical technology and the clinical microbiology insight needed to create a breath test for infections has seen a considerable number of advances and there are now numerous research teams focused on evaluating patient breath as a diagnostic fluid for infectious diseases. Significant challenges still need to be overcome.

From Pittcon 27 Feb 2017

New humanized model enables better characterization of Alzheimer's pathology

Cells behave differently when removed from their environments, just as cells that develop in cultures do not behave like cells in living creatures.

24 Feb 2017

Precise inactivation of neurotransmitter receptors using CALI technique erases fear memory in mice

The delivery of chemical messenger (neurotransmitter) receptors to the junctions between nerve cells (synapses) is crucial to cognitive processes such as memory.

23 Feb 2017

Scientists engineer smallest CRISPR-Cas9 system to date

Scientists at the Center for Genome Engineering, within the Institute for Basic Science0, in collaboration with KIM Eunji and KIM Jeong Hun have engineered the smallest CRISPR-Cas9 to date, delivered it to the muscle cells and in the eyes of mice via adeno-associated viruses and used it to modify a gene causing blindness.

21 Feb 2017

Researchers develop novel in vivo model for studying pancreatic cancer

Researchers at Okayama University report in the December 2016 issue of the American Journal of Cancer Research a novel in vivo model for the study of pancreatic ductal adenocarcinoma (PDAC) tumors.

21 Feb 2017

New approach could make organometallic catalysis applicable for therapy or diagnostics

A gold catalyst can be delivered to a target organ in a higher organism where it performs a chemical transformation visualized by bioimaging.

17 Feb 2017

Study provides insight into how microRNA may amplify effects of drug treatment in liver cancer

Treatment options for liver cancer are often limited and almost exclusively involve transplantation if possible, or local chemoembolization and radiofrequency ablation.

17 Feb 2017

Study shows potential of 3D tracking system in improving accuracy of robot-assisted surgery

The cutting-edge biocompatible near-infrared 3D tracking system used to guide the suturing in the first smart tissue autonomous robot surgery has the potential to improve manual and robot-assisted surgery and interventions through unobstructed 3D visibility and enhanced accuracy, according to a study published in the March 2017 issue of IEEE Transactions on Biomedical Engineering.

17 Feb 2017

Salk scientists use mRNA to successfully treat hemophilia B in mice

FedEx, UPS, DHL--when it comes to sending packages, choices abound. But the most important delivery service you may not have heard of mRNA.

16 Feb 2017

Research opens treatment pathways for cancers that do not respond to targeted antibodies

By hijacking a cancer cell's own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsive to conventional targeted antibodies, such as triple-negative breast cancer.

15 Feb 2017

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

Nicotine -- the primary compound found within tobacco smoke -- is known to change the grouping of some subtypes of nicotinic receptors, but the mechanisms for nicotine addiction remain unclear.

15 Feb 2017

New study reveals potential drug to combat life-threatening effects of COPD

New research published online in The FASEB Journal reveals a potential drug to combat the life-threatening effects of chronic obstructive pulmonary disease (COPD).

13 Feb 2017

Specific genetic errors that trigger congenital heart disease can be reproduced in common fruit fly

Specific genetic errors that trigger congenital heart disease (CHD) in humans can be reproduced reliably in Drosophila melanogaster - the common fruit fly - an initial step toward personalized therapies for patients in the future.

11 Feb 2017

InnovationDB conducts study to explore use of plastic electronics in healthcare devices

Now is the time for healthcare innovators to adopt plastic electronics and revolutionise healthcare monitoring and diagnosis. InnovationDB, the world’s largest IP licensable technology database, has carried out a comprehensive study of the use of plastic electronics in healthcare devices to spot the biggest trends and identify the full potential of this exciting technology to transform our lives.

10 Feb 2017

in vivo News and Research

Using Spherical Nucleic Acids to Track and Treat Disease

Study suggests new strategy for treating Alzheimer's disease

Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

SBP researchers identify new regulator of innate immune response to foreign invaders

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

Researchers aim to develop sustained and controllable insulin release system for treatment of diabetes

Diagnosing Infections Through Molecules in Patient Breath

New humanized model enables better characterization of Alzheimer's pathology

Precise inactivation of neurotransmitter receptors using CALI technique erases fear memory in mice

Scientists engineer smallest CRISPR-Cas9 system to date

Researchers develop novel in vivo model for studying pancreatic cancer

New approach could make organometallic catalysis applicable for therapy or diagnostics

Study provides insight into how microRNA may amplify effects of drug treatment in liver cancer

Study shows potential of 3D tracking system in improving accuracy of robot-assisted surgery

Salk scientists use mRNA to successfully treat hemophilia B in mice

Research opens treatment pathways for cancers that do not respond to targeted antibodies

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

New study reveals potential drug to combat life-threatening effects of COPD

Specific genetic errors that trigger congenital heart disease can be reproduced in common fruit fly

InnovationDB conducts study to explore use of plastic electronics in healthcare devices

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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