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German scientists develop new approach to prevent GvHD after bone marrow transplants

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants.

16 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not.

12 Aug 2016

MPFI researchers induce and visualize formation of new synapses in real time in live animals

The formation of excitatory and inhibitory synapses between neurons during early development gives rise to the neuronal networks that enable sensory and cognitive functions in humans.

11 Aug 2016

Understanding brain circuit development: an interview with Dr Hollis Cline

There's a tremendous amount known about brain circuit development. Our work was inspired by experiments that were done over 50 years ago by scientists at Harvard University, Hubel and Wiesel. They received a Nobel Prize for their work and have inspired many additional experiments over the last 50 or 60 years.

10 Aug 2016

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

New research from University College London, Moorfields Eye Hospital and Duke University School of Medicine has identified a gene that drives scarring, together with a rapidly translatable therapy, for the UK's most common cause of blinding conjunctivitis.

4 Aug 2016

Research could help develop better therapies for new subtype of adenocarcinoma patients

Lung cancer is the most common cause of cancer deaths, accounting for about a third of all tumor-related deaths. Adenocarcinomas, a non-small cell lung cancer (NSCLC), account for about 40 percent of cancer diagnoses, but few treatments are available for the disease.

4 Aug 2016

New drug prevents vaginal and oral transmission of HIV in pre-clinical animal models

HIV remains a major health concern for women and children globally. Worldwide, the majority of new HIV infections occur in young women. Each year, 1.5 million women living with HIV become pregnant.

2 Aug 2016

Study clarifies role of KLF12 in CRC tumor growth

Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One, demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. Furthermore, data demonstrate that KLF12 and EGR1 levels synergistically correlate with poor CRC prognoses.

29 Jul 2016

Microswimmer robots could help deliver medicine and perform surgery inside the body

Drexel University researchers, led by MinJun Kim, PhD, a professor in the College of Engineering, have successfully pulled off a feat that both sci-fi fans and Michael Phelps could appreciate.

29 Jul 2016

Salmonella protein can reduce drug resistant molecule found in cancer cells

A surprising result in an experiment on Salmonella bacteria has led to a discovery that may make drug resistant cancer cells more treatable by conventional chemotherapies.

25 Jul 2016

Predictive power of computational toxicology demonstrated with crowd-sources scientific challenge

Results of the Systems Toxicology Computational Challenge have demonstrated how transcriptomics information present in the blood can be used to predict whether people have been exposed or not exposed to specific toxicants.

22 Jul 2016

New study identifies alternative route for tuberculosis infection

Researchers from UT Southwestern Medical Center have identified a new way that tuberculosis bacteria get into the body, revealing a potential therapeutic angle to explore.

22 Jul 2016

New study reports strains of chimpanzee-carried SIVs can infect human cells

No one knows exactly how it happened. It may have entered through a cut or bite wound, the blood of a chimpanzee seeping into an exposed fingertip or forearm or foot.

22 Jul 2016

Study suggests failure of specialised beta cells may lead to diabetes

The significant role of beta cell 'hubs' in the pancreas has been demonstrated for the first time, suggesting that diabetes may due to the failure of a privileged few cells, rather than the behaviour of all cells.

21 Jul 2016

Scientists develop new optical fiber-based probe for brain temperature measurements

The brain is the most temperature-sensitive organ in the body. Even small deviations in brain temperature are capable of producing profound effects--including behavioral changes, cell toxicity, and neuronal cell death. The problem faced by researchers and clinicians is how to measure and understand the

20 Jul 2016

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Using a robust model for Parkinson's disease, University of Alabama at Birmingham researchers and colleagues have discovered an interaction in neurons that contributes to Parkinson's disease, and they have shown that drugs now under development may block the process.

20 Jul 2016

New research shows how toxic Alzheimer's protein spreads through the brain

A toxic Alzheimer's protein can spread through the brain--jumping from one neuron to another--via the extracellular space that surrounds the brain's neurons, suggests new research from Columbia University Medical Center.

19 Jul 2016

Researcher aims to make early detection of melanoma faster, cheaper without need for biopsy

Melanoma is a form of skin cancer that becomes dangerous when it spreads, but is treatable in its early stages. Doctors diagnose melanoma by cutting away a piece of a suspicious skin lesion -- a procedure known as a biopsy -- and testing it for malignant cells.

14 Jul 2016

Researchers reveal molecular mechanism of autophagy initiation

Researchers revealed that Atg13 links autophagy initiation factors to each other using a string-like conformation, thereby promoting the association of diverse elements of the autophagy initiation machinery, initiating autophagosome formation through the recruitment of Atg9 vesicles and phosphorylation of various Atg factors.

12 Jul 2016

in vivo News and Research

German scientists develop new approach to prevent GvHD after bone marrow transplants

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

MPFI researchers induce and visualize formation of new synapses in real time in live animals

Understanding brain circuit development: an interview with Dr Hollis Cline

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

Research could help develop better therapies for new subtype of adenocarcinoma patients

New drug prevents vaginal and oral transmission of HIV in pre-clinical animal models

Study clarifies role of KLF12 in CRC tumor growth

Microswimmer robots could help deliver medicine and perform surgery inside the body

Salmonella protein can reduce drug resistant molecule found in cancer cells

Predictive power of computational toxicology demonstrated with crowd-sources scientific challenge

New study identifies alternative route for tuberculosis infection

New study reports strains of chimpanzee-carried SIVs can infect human cells

Study suggests failure of specialised beta cells may lead to diabetes

Scientists develop new optical fiber-based probe for brain temperature measurements

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

New research shows how toxic Alzheimer's protein spreads through the brain

Researcher aims to make early detection of melanoma faster, cheaper without need for biopsy

Researchers reveal molecular mechanism of autophagy initiation

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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