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Novel approach improves CAR T-cell therapy efficacy against acute myeloid leukemia

St. Jude Children's Research Hospital scientists improved chimeric antigen receptor (CAR) T–cell immunotherapy for acute myeloid leukemia (AML), demonstrating better efficacy in the lab.

12 Feb 2024

Drug repurposing study finds lonafarnib effective against RSV

A study in Nature Communications identifies lonafarnib from the ReFRAME drug-repurposing library as a potent inhibitor of the RSV fusion protein, showing promise in reducing RSV infection in vitro and in vivo.

11 Feb 2024

New study finds 4’-fluorouridine effective against avian influenza in vitro and in vivo

A PLOS Pathogens study reveals 4’-fluorouridine effectively combats avian influenza in vitro and in animal models, showing promise as a treatment that overcomes resistance and reduces disease severity without significant adverse effects.

11 Feb 2024

New MRI method enables early detection and better monitoring of multiple sclerosis

Multiple sclerosis (MS) is a neurological disease that usually leads to permanent disabilities. It affects around 2.9 million people worldwide, and around 15,000 in Switzerland alone.

8 Feb 2024

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

A tiny device built by scientists at MIT and the Singapore-MIT Alliance for Research and Technology could be used to improve the safety and effectiveness of cell therapy treatments for patients suffering from spinal cord injuries.

7 Feb 2024

Researchers uncover how deadly MRSA pneumonia inhibits body's antimicrobial activity

Researchers examined how heparan sulfate (HS) shedding impacts cathelicidin efficacy in Methicillin-Resistant Staphylococcus aureus (MRSA) pneumonia.

7 Feb 2024

What natural compounds can help you manage your rosacea?

Researchers reviewed existing data on rosacea management using botanicals.

7 Feb 2024

Promising influenza drug candidate shows activity against resistant variants

Influenza A viruses with induced resistance to a new candidate antiviral drug were found to be impaired in cell culture and weakened in animals, according to a study by researchers in the Center for Translational Antiviral Research at Georgia State University.

6 Feb 2024

Interdisciplinary dream team receives $3 million grant to revolutionize Alzheimer's diagnosis

What do a synthetic chemist, a medical imaging expert, and a neurologist have in common? They're coming together in the Biomedical Imaging Center at the Beckman Institute for Advanced Science and Technology to develop better diagnostic tools and imaging agents to detect early-stage Alzheimer's disease and other neurodegenerative diseases.

6 Feb 2024

Revvity showcases cutting-edge solutions at SLAS2024

Revvity presents its continued commitment to expanding the boundaries of human potential through science.

From Revvity 5 Feb 2024

Breakthrough gene-editing therapy transforms lives of patients with a hereditary disorder

A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher.

2 Feb 2024

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

Is there an association between vitamin D, immunocompetence, and aging?

The role of an individual’s immunocompetence in the responsiveness to vitamin D.

1 Feb 2024

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

NewsMedical speaks with Chao Ma, Ph.D. a Research Assistant Professor at New York University Tandon School of Engineering, ahead of his presentation at SLAS 2024.

From Society for Laboratory Automation and Screening (SLAS) 29 Jan 2024

How does the nasal cavity's immune system combat SARS-CoV-2?

Researchers discovered that CD4+ and CD8+ T cells play a crucial role in clearing COVID-19 infection in the nasal cavity but have limited impact on lung infections, with implications for understanding and treating the virus.

28 Jan 2024

New brain implant records neuron activity for months

Recording the activity of large populations of single neurons in the brain over long periods of time is crucial to further our understanding of neural circuits, to enable novel medical device-based therapies and, in the future, for brain–computer interfaces requiring high-resolution electrophysiological information.

27 Jan 2024

Prime editing takes gene therapy to the next level

This study is led by Prof. Xianqun Fan (Department of Ophthalmology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital).

27 Jan 2024

Mapping the neural pathways of thirst and salt satiety

Staying hydrated and consuming appropriate amounts of salt is essential for the survival of terrestrial animals, including humans.

27 Jan 2024

in vivo News and Research

Novel approach improves CAR T-cell therapy efficacy against acute myeloid leukemia

Drug repurposing study finds lonafarnib effective against RSV

New study finds 4’-fluorouridine effective against avian influenza in vitro and in vivo

New MRI method enables early detection and better monitoring of multiple sclerosis

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

Monash-led study unveils potential long-term treatment for lupus

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

Researchers uncover how deadly MRSA pneumonia inhibits body's antimicrobial activity

What natural compounds can help you manage your rosacea?

Promising influenza drug candidate shows activity against resistant variants

Interdisciplinary dream team receives $3 million grant to revolutionize Alzheimer's diagnosis

Revvity showcases cutting-edge solutions at SLAS2024

Breakthrough gene-editing therapy transforms lives of patients with a hereditary disorder

CRISPR revolutionized: New method edits genes directly in the body

Is there an association between vitamin D, immunocompetence, and aging?

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

How does the nasal cavity's immune system combat SARS-CoV-2?

New brain implant records neuron activity for months

Prime editing takes gene therapy to the next level

Mapping the neural pathways of thirst and salt satiety

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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