p53 Protein News and Research

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The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian of the genome” as it helps in regulating the cell cycle and acts as a tumor suppressor.

Enzyme sphingosine kinase 2 show to be potential new target to fight cancer

Researchers at the Virginia Commonwealth University Massey Cancer Center have identified the enzyme sphingosine kinase 2 as a possible new therapeutic target to improve the efficacy of chemotherapy for colon and breast cancer.

2 Nov 2007

New model of esophageal cancer

In the November 1st issue of G&D, a team of scientists led by Dr. Anil Rustgi (UPENN) presents an innovative new model of esophageal cancer, which holds great promise as an experimental platform to investigate the etiology and possible treatment of this devastating disease.

1 Nov 2007

Advances in drug screening

With the discovery of suitable molecular targets - cellular molecules along pathways crucial for sustaining the life of cancer cells - comes the perplexing dilemma of where to find the next therapeutics that will bind to and disable those targets.

23 Oct 2007

Researchers improve accuracy of breast cancer prognoses

One of the many unknowns facing women who are diagnosed with breast cancer is predicting the likelihood that the cancer will spread to other parts of the body – metastasize.

17 Oct 2007

Dmp1 gene and lung cancer

The first research to show the involvement of a gene known as Dmp1 in human lung cancer will hopefully lead to an increased understanding on what goes wrong at the cellular level to cause the disease, according to researchers from Wake Forest University School of Medicine reporting in Cancer Cell .

16 Oct 2007

Genome update defines landscape of breast and colon cancers

One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers.

12 Oct 2007

Biologists link Huntington's disease to health benefits in young

For years researchers in neurology have believed that people with Huntington's disease have more children than the general population because of behavioral changes associated with the disease that lead to sexual promiscuity.

26 Sep 2007

Trop-2 new target for anti-tumour therapy in cancer

Italian scientists announced (Monday September 24) that they have found a new and promising target for anti-tumour therapy in cancer.

25 Sep 2007

Ancient mechanism for coping with stresses also gives cancer a boost

An ancient mechanism for coping with environmental stresses, including heat and toxic exposures, also helps cancerous tumors survive, reveals a new report in the Sept. 21, 2007, issue of Cell, a publication of Cell Press.

21 Sep 2007

New insight into breast cancer development in high-risk women

Physicians who treat women with the breast cancer susceptibility gene BRCA1 often remove their patients' ovaries to eliminate the source of estrogen they believe fuels cancer growth.

12 Sep 2007

In the junk lies treasure when it comes to DNA

Three micro RNA genes appear to be key partners of protective gene p53; their loss is linked to common type of lung cancer

24 Aug 2007

Metformin kills some cancer cells

Researchers at the University of Pennsylvania School of Medicine have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53.

16 Aug 2007

New pathway for inflammation-induced cancer

A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells, researchers at The University of Texas M. D. Anderson Cancer Center report in the August edition of the journal Cell .

11 Aug 2007

Moderate amounts of caffeine along with exercise can be good for your health

Regular exercise and little or no caffeine has become a popular lifestyle choice for many Americans.

1 Aug 2007

Protein IKKa protects checkpoint gene from chemical shutdown

A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced, researchers at The University of Texas M. D. Anderson Cancer Center report in the July 20 edition of Molecular Cell.

20 Jul 2007

Anti-cancer gene p53 doubles up as anti-ageing agent

The latest research suggests that one of the genes that protects us from cancer may also help delay the ageing process.

19 Jul 2007

Scientists develop largest ever series of human breasts cancers grafted into mice

At the Institut Curie, Inserm researchers and physicians have established the largest ever panel of human breast cancer xenografts in animal models.

13 Jul 2007

African-Americans women more likely to present with later stage and higher grade breast cancer tumors compared to Caucasians

African-American women are diagnosed with more advanced breast cancer than Caucasians, according to a new, single hospital study.

10 Jul 2007

Breast cancers to be more aggressive in African-American women

A study of more than 2,200 women at the Kimmel Cancer Center at Jefferson in Philadelphia shows that African American women have more advanced breast cancer at the time of diagnosis than Caucasian women.

10 Jul 2007