p53 Protein News and Research

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The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian of the genome” as it helps in regulating the cell cycle and acts as a tumor suppressor.

New testing approach to predict outcome in patients with bladder cancer

A new testing approach has been shown to be effective in identifying patients at the highest risk of cancer relapse after surgery for bladder cancer, say researchers in the February issue of The Lancet Oncology.

29 Jan 2007

Kaposi's sarcoma-associated herpesvirus tricks cells to become tumors

Researchers at the University of Pennsylvania School of Medicine have discovered how the Kaposi's sarcoma-associated herpesvirus (KSHV) subverts a normal cell process in order to promote tumor growth.

8 Nov 2006

Gene amplification links growth controlling pathway from Drosophila to human cancers

Researchers at Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) have discovered a new cancer-promoting role for a gene potentially involved in breast, liver, and other kinds of cancers.

8 Aug 2006

Oral cancers - smoke and drink and up goes the risk!

Scientists in the UK have discovered that mouth cancer develops in two distinct ways which decides just how the serious the disease will be.

2 Aug 2006

Scientists identifiy the way MDM2 protein can trigger the spread of cancer

The protein, MDM2, normally functions to control the activity of a key cancer preventing protein called p53.

25 Jul 2006

An accurate model of p53 tumor suppressor protein bound to DNA for anti-cancer activity

More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending against cancer.

18 Jul 2006

Scientists discover promising new therapeutic target for heart disease

Scientists at the Boston Biomedical Research Institute identified Puma (p53 upregulated modulator of apoptosis) as a potential new target for the therapeutic intervention of heart disease.

10 Jul 2006

Promising chemo, therapeutic viruses, cutting-edge surgery debut at M. D. Anderson Cancer Center

Brain tumor specialists at The University of Texas M. D. Anderson Cancer Center are poised on the brink of a new era.

10 May 2006

Scientists discover molecular security mechanism for keeping gene mutations in check

Everyone knows mutations - genetic mistakes in DNA, the material of heredity - are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing.

8 May 2006

New model of p53 regulation has important implications for the development of anticancer drugs

Genetically engineered mice convinced scientists at the Salk Institute for Biological Studies that it was time to overhaul widely held beliefs about how a powerful tumor suppressor called p53 is controlled in cells. Their new model of p53 regulation has important implications for the development of anticancer drugs.

11 Apr 2006

Increase in Vitamin E tied to fewer in utero deaths

Manipulating the in utero environment may alter the onset of cancers that appear later in the lives of mammals, according to a new University of Toronto study published in the journal Carcinogenesis.

23 Mar 2006

Man-made chemical compound targets and kills tumor cells

A man-made chemical compound called ARC causes tumor cells to die but leaves normal cells unharmed, researchers at the University of Illinois at Chicago report in a study highlighted in the March 15 issue of Cancer Research.

15 Mar 2006

Study identifies compounds that overcome a specific type of resistance to chemotherapeutic-induced apoptosis

Treatment of human cancer is often impeded when cancer cells develop resistance to drugs that are designed to induce a type of programmed cell death called apoptosis.

16 Feb 2006

DNA polymerase zeta gives cells with damaged DNA a new lease on life

Fortunately, our cells contain many enzymes devoted strictly to detecting and repairing any damage caused by these insults. In fact, failure of these enzymes to make needed repairs to genes can lead to the accumulation of mutations and, eventually, cell death or possibly cancer.

6 Jan 2006

Gene mapping project promises new targeted cancer therapies

Government researchers in the United States have this week launched a pilot project to find all the little genetic changes that cause cancer in the hope it will lead to a whole new world of targeted cancer therapy.

14 Dec 2005

Critical role of p53 gene

Fruit flies can live significantly longer, and remain healthy, when activity of the fly version of the tumor-suppressing protein p53 is reduced in nerve cells.

21 Nov 2005

Cell fusion triggered by viruses is a possible contributing factor in the development of human cancer

In some cases, the fusion of human cells is a normal process that leads, for instance, to the formation of muscle and bone. Viral infections can also cause cell fusion, but cells fused by viruses are widely considered to be harmless because they are generally believed to die without consequences for the host.

7 Nov 2005

Novel mouse model of medulloblastoma

A collaboration of researchers, led by Dr. Martine Roussel of St. Jude Children's Research Hospital, has developed a novel mouse model of medulloblastoma -- the most prevalent malignant pediatric brain tumor -- that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.

30 Oct 2005

Chromosomes in the nucleus of the cell carry the material of heredity, or genes

Abnormal cell division that yields cells with an extra set of chromosomes can initiate the development of tumors in mice, researchers at Dana-Farber Cancer Institute have shown, validating a controversial theory about cancer causation put forth by a scientific visionary nearly 100 years ago.

12 Oct 2005

RPL26 and nucleolin play critical roles in controlling the production of p53

Investigators at St. Jude Children's Research Hospital have discovered a previously unrecognized mechanism that controls a key protein linked to the cell's response to stress - a finding that holds promise for new ways to enhance cancer therapies or protect cells from dying after exposure to damaging chemicals or radiation.

9 Oct 2005