siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.
Researchers describe novel mechanism that links epigenetic change to translational control

Researchers describe novel mechanism that links epigenetic change to translational control

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Researchers describe link between poor oocyte development and oxidative stress in obese mice

Researchers describe link between poor oocyte development and oxidative stress in obese mice

FDA approves first targeted RNA-based treatment for rare, fatal genetic disease

FDA approves first targeted RNA-based treatment for rare, fatal genetic disease

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam achieves delivery of novel siRNAs conjugates to the central nervous system

Alnylam achieves delivery of novel siRNAs conjugates to the central nervous system

Scientists discover a small family of proteins that control inclusion of DNA methylation marks in genome

Scientists discover a small family of proteins that control inclusion of DNA methylation marks in genome

Sylentis presents clinical study results of new treatment for dry eye syndrome

Sylentis presents clinical study results of new treatment for dry eye syndrome

Novel cell-based screening array reduces time and cost of drug discovery

Novel cell-based screening array reduces time and cost of drug discovery

Newly designed three-part molecule shows promise to treat breast cancers

Newly designed three-part molecule shows promise to treat breast cancers

New study shows advantages of DNA barcoding technique for identifying nanoparticles

New study shows advantages of DNA barcoding technique for identifying nanoparticles

New modular platform offers robust biological approach that targets endless number of diseases

New modular platform offers robust biological approach that targets endless number of diseases

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies

Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies

Retinal diseases could be treated by ophthalmic drops instead of intraocular injections

Retinal diseases could be treated by ophthalmic drops instead of intraocular injections

Texas Biomedical Research Institute tests promising new treatment for HBV infection

Texas Biomedical Research Institute tests promising new treatment for HBV infection

Researchers win $1.4 million federal grant to study new treatment approaches for intestinal inflammation

Researchers win $1.4 million federal grant to study new treatment approaches for intestinal inflammation

Study demonstrates potential nanoparticle-based therapeutic strategy for deadly brain tumors

Study demonstrates potential nanoparticle-based therapeutic strategy for deadly brain tumors

Genetic manipulation of exosomes may offer new therapeutic approach to treating pancreatic cancer

Genetic manipulation of exosomes may offer new therapeutic approach to treating pancreatic cancer