siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.
Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Study shows new RNA letter as regulatory key to control gene expression

Study shows new RNA letter as regulatory key to control gene expression

RXi Pharmaceuticals begins Phase 1/2 clinical trial in ophthalmology

RXi Pharmaceuticals begins Phase 1/2 clinical trial in ophthalmology

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

RXI-109 use after scar revision surgery has beneficial effect on suppression of hypertrophic scarring

RXI-109 use after scar revision surgery has beneficial effect on suppression of hypertrophic scarring

NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells

NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

EnGeneIC begins Phase 1 Tailored-EDV trial for advanced solid tumor

EnGeneIC begins Phase 1 Tailored-EDV trial for advanced solid tumor

IDT webinar explores effective RNAi and antisense oligo methods

IDT webinar explores effective RNAi and antisense oligo methods

Researchers use advanced photodynamic therapy to combat ovarian cancer in laboratory animals

Researchers use advanced photodynamic therapy to combat ovarian cancer in laboratory animals

Scientists reveal potential therapeutic approach to idiopathic pulmonary fibrosis

Scientists reveal potential therapeutic approach to idiopathic pulmonary fibrosis

Trends, R&D progress, and predicted revenues in RNAi therapies

Trends, R&D progress, and predicted revenues in RNAi therapies

University of Leeds scientists uncover genes implicated in common inherited diseases

University of Leeds scientists uncover genes implicated in common inherited diseases

RXi Pharmaceuticals receives Notice of Allowance from USPTO for novel, self-delivering RNAi platform

RXi Pharmaceuticals receives Notice of Allowance from USPTO for novel, self-delivering RNAi platform

Alnylam files clinical trial application for alpha-1 liver disease, presents data at DDW

Alnylam files clinical trial application for alpha-1 liver disease, presents data at DDW

Non-coding RNAs in maternal food can pass through placenta to regulate fetal gene expression

Non-coding RNAs in maternal food can pass through placenta to regulate fetal gene expression

Case Western Reserve researchers find potential game-changer for triple-negative breast cancer

Case Western Reserve researchers find potential game-changer for triple-negative breast cancer

Scientists develop nanoneedle technique to generate new blood vessels

Scientists develop nanoneedle technique to generate new blood vessels

Experimental nanoparticle therapy speeds healing of all sorts of wounds

Experimental nanoparticle therapy speeds healing of all sorts of wounds

MTfp-­siRNA reduces blood vessel infarct, improves overall brain activity in ischemic stroke model

MTfp-­siRNA reduces blood vessel infarct, improves overall brain activity in ischemic stroke model