siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.
Innovative therapy offers new hope to breast cancer patients

Innovative therapy offers new hope to breast cancer patients

Ikaria shareholders to sell Commercial Business to Madison Dearborn Partners

Ikaria shareholders to sell Commercial Business to Madison Dearborn Partners

Alnylam initiates Phase II study with ALN-TTRsc for treatment of ATTR

Alnylam initiates Phase II study with ALN-TTRsc for treatment of ATTR

NIH data-sharing may advance genetic and translational research, therapeutic target discovery

NIH data-sharing may advance genetic and translational research, therapeutic target discovery

Alnylam presents new pre-clinical data with ALN-AT3 for treatment of hemophilia and RBD

Alnylam presents new pre-clinical data with ALN-AT3 for treatment of hemophilia and RBD

Arrowhead reports Phase 1 study data on ARC-520 for treatment of chronic hepatitis B infection

Arrowhead reports Phase 1 study data on ARC-520 for treatment of chronic hepatitis B infection

Arrowhead seeks approval to start ARC-520 phase 2a trial for chronic hepatitis B infection

Arrowhead seeks approval to start ARC-520 phase 2a trial for chronic hepatitis B infection

Reduced SMG1 protein expression may contribute to neurological disorders

Reduced SMG1 protein expression may contribute to neurological disorders

MIT researchers design stealth drug delivery system to attack TNBC cells

MIT researchers design stealth drug delivery system to attack TNBC cells

"One-two punch" disables tumors' defenses

"One-two punch" disables tumors' defenses

Molecular Templates secures $8.5M series C financing plus $10.6M grant from CPRIT

Molecular Templates secures $8.5M series C financing plus $10.6M grant from CPRIT

Alnylam advances Development Candidate for ALN-AS1 for treatment of hepatic porphyrias

Alnylam advances Development Candidate for ALN-AS1 for treatment of hepatic porphyrias

Arrowhead initiates Phase 1 study of ARC-520 for treatment against chronic HBV infection

Arrowhead initiates Phase 1 study of ARC-520 for treatment against chronic HBV infection

Cholesterol-lowering drugs could be alternative treatment for people who take statins

Cholesterol-lowering drugs could be alternative treatment for people who take statins

Researchers develop innovative system to test how virus interacts with cells in body

Researchers develop innovative system to test how virus interacts with cells in body

Shire extends existing partnership with Santaris Pharma in rare genetic disease space

Shire extends existing partnership with Santaris Pharma in rare genetic disease space

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Strategy that dismantles flu viral genome in human lung cells ensures safe research

Strategy that dismantles flu viral genome in human lung cells ensures safe research

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

FDA grants orphan drug designation to ARMAGEN's AGT-182 for treatment of Hunter syndrome

FDA grants orphan drug designation to ARMAGEN's AGT-182 for treatment of Hunter syndrome