Coronaviruses are huge, encapsulated, non-segmented positive-sense RNA viruses that are well-known to impact birds, mammals and humans. The evolution of the novel SARS-CoV-2 virus, which is responsible for causing the current COVID-19 pandemic, has been the biggest public health crisis of the 21st century.
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This virus is more dangerous than MERS-CoV and SARS-CoV combined together and is referred to as SARS-CoV-2. The genome sequence of SARS-CoV-2 is roughly 51.8% analogous to the MERS-CoV, about 79% analogous to SARS-CoV, and around 87% analogous to other SARS-like coronaviruses that emerged from Chinese bats.
SARS-CoV-2 is known to have four essential structural proteins called the Spike, Membrane, Envelope and the Nucleocapsid protein that is utilized in the virion assembly. The Spike protein regulates the entry of the virus and is the main determinant of the tropism and pathogenesis of cells. It denotes one of the most crucial targets for designing therapeutics and vaccines.
The Nucleocapsid protein — a highly immunogenic antigen — contains specific anti-N protein antibodies that are detected in the patient’s serum around 5 to 10 days after infection.
Since limited data is available about the role of the SARS-CoV-2 proteins in the pathogenesis and replication of viruses, there were not many treatment options. In addition, only limited research tools are available in the market.
BioVision provides a range of products to support coronavirus studies. These products include ELISA, assay kits, antibodies, proteins, anti-viral agents and a host of other products. Such research products can help scientists in investigating MERS, SARS and SARS-CoV-2 coronaviruses.
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