CD155 Molecule Synonym Name
PVR, FLJ25946, PVS, CD155, TAGE4, HVED, NECL5
CD155 Molecule Background
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells.
The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus.
Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.
- Mendelsohn CL, Wimmer E, Racaniello VR, 1989, Cell 56 (5): 855¨C65 .
- Maier MK, Seth S, Czeloth N, et al., 2007, European Journal of Immunology 37 (8): 2214.
- Koike, H. et al., 1990, EMBO J. 9:3217.
- Zhang P, Mueller S, Morais MC. Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18284¨C9.
- Zhang P., et al., 2008, Proc. Natl. Acad. Sci., 105 (47): 18284-18289.
- Maier MK., et al., 2007, European Journal of Immunology, 37 (8): 2214-2225.
- He Y., et al., 2000, Proc. Natl. Acad. Sci., 97 (1): 79-84.
CD155 Related Molecule