CD28 Molecule Information
Name：T-cell-specific surface glycoprotein CD28
Target Synonym：CD28?T-cell-specific surface glycoprotein CD28?TP44?CD_antigen=CD28
Number of Launched Drugs：0
Number of Drugs in Clinical Trials：11
Lastest Research Phase：Phase ?
CD28 Molecule Synonym Name
CD28 Molecule Background
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2).
When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
- Woerly G., et al., 2002, J Leukoc Biol 72 (4): 769¨C79.
- Nun¨¨s, J A., et al., 1996, J. Biol. Chem. (UNITED STATES) 271 (3): 1591¨C8.
- Ellis, J H., et al., 2000, J. Immunol. (UNITED STATES) 164 (11): 5805¨C14.
CD28 Related Molecule