CD38 Molecule Information
Name：Lymphocyte differentiation antigen CD38
Target Synonym：2 -phospho-ADP-ribosyl cyclase?T10?CD38?2 -phospho-cyclic-ADP-ribose transferase?CD_antigen=CD38?2 -phospho-ADP-ribosyl cyclase/2 -phospho-cyclic-ADP-ribose transferase?ADPRC 1?Cyclic ADP-ribose hydrolase 1?ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Number of Launched Drugs：1
Number of Drugs in Clinical Trials：6
Lastest Research Phase：Approved
CD38 Molecule Synonym Name
CD38, T10, cADPr hydrolase 1
CD38 Molecule Background
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose.
These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.