CD47 Molecule Information
Name：Cluster of Differentiation 47
Target Synonym：Protein MER6?Integrin-associated protein?Antigenic surface determinant protein OA3?Leukocyte surface antigen CD47?CD47?MER6?CD_antigen: CD47
Number of Launched Drugs：0
Number of Drugs in Clinical Trials：11
Lastest Research Phase：Phase ?
CD47 Molecule Synonym Name
CD47, MER6, IAP, OA3
CD47 Molecule Background
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity.
CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
CD47 Related Molecule