Chirascan™ Q100 Spectrometer - Discover Characteristics of Complex Biomolecules

The Chirascan Q100 is a high-tech CD spectrometer with precise robotics, which can provide researchers with data of extremely high quality, allowing adherence to the strictest statistical analyses.

The Chirascan Q100 allows researchers to probe and quantify the Higher Order Structure (HOS) of large biomolecules. The instrument’s high data quality allows statistically-valid, objective comparisons of HOS to be made.

Fully integrated for unmanned operation, the Chirascan Q100 saves days of operator time, analyzing 48 buffer-sample pairs in 24 hours. Whereas a skilled operator can only process up to 14 samples per day on a manual system.

  • Molecular sieve, activated charcoal filter
    • Removes common gas impurities
  • Fixed Flow Cells
    • Choice of pathlength to optimize concentration and absorbance
    • Eliminates errors of cuvette handling
    • Recognized by Chirascan Control to choose run/wash/dry protocols

  • Monochromator
    • Generates horizontally, linearly polarized monochromatic light
    • Dual polarizing prisms maximize light throughput
  • Photoelastic Modulator
    • Used to transfer horizontal polarization to circular polarization (L or R)
  • Air-Cooled Xenon Lamp
    • Software controlled
    • Up-time recorded
  • Active Nitrogen Management System
    • Purge gas consumption can be regulated via a software-controlled system
  • Integrated Autosampler
    • Eliminate sample handling errors
    • Temperature controlled storage maintains sample integrity
    • Precise liquid handling and reproducibility
  • Avalanche Photodiode Detector
    • Ultra sensitive with a high signal: noise ratio
  • Multiwavelength Calibration
    • To provide CD accuracy at any wavelength
  • Temperature Controlled Sample Chamber
    • Consistent analytical conditions
    • Continuous temperature ramps (single sample mode)
  • Water Circulator
    • Dissipates heat from sample chamber and sample storage Peltiers
  • Cuvettes and Holders
    • Selected for far- and near-UV CD analysis of biomolecules (single sample mode)
  • Global Thermodynamic Analysis
    • Obtain melting points and enthalpies from multi-wavelength, thermal denaturation experiments (single sample mode)
  • HOS Comparison Software
    • Make statistically-validated comparisons
  • Control and Analysis Software
    • Saves time with scheduled start-up/shutdown of lamp and N2 supply

    • Recognizes flow cell to choose ideal run/wash/dry protocol

    • Ensures O2-free conditions with N2 purge

    • Easily defined run parameters and store standard protocols

    • Fail-safe lamp switch-off if N2 flow drops