Combined Contractility, Electrophysiology, and Cell Viability—CardioExcyte 96

The CardioExcyte 96 system available from Nanion Technologies is a hybrid system that can record both electrophysiology and contractility of intact cardiomyocyte networks. Moreover, the base impedance is automatically and constantly tracked as a measure of chronic and acute cell activity.

The subtleties of cytotoxic responses are not missed, even for non-contractile cell types like cancer cells or hepatocyte-like cells, and even contractile cardiac cells.

Measurements of extracellular field potential and impedance are carried out at high resolution in a label-free and non-invasive manner. The CardioExcyte 96 is a completely automatic device that records from 96 wells in parallel.

Listed below are the benefits of CardioExcyte 96:

  • New supplementary FLEXcyte 96 for contractility under physiological conditions
  • Label-free and non-invasive measurements
  • Extracellular field potentials and impedance measured from the same well
  • Recording performed from 96 wells at the same time
  • High resolution
  • Optical and electrical pacing options
  • Forms part of the CiPA validation study
  • Chronic and acute evaluation of toxicity and cell activity

Thanks to its advanced sensor technology and embedded electronics combined with the well-plate-based consumables, the CardioExcyte 96 is a ready-to-run system for efficient measurements of extracellular field potential and impedance.

The CardioExcyte 96 package comes with an Incubation System that avoids the need for using a separate incubator. The system is fixed on the bench-top with constant control over the gas mix, humidity, and temperature.

A superior software package for data handling and export ensures user-friendly operation and efficiency—this forms a vital part of the CardioExcyte 96 system. The system has been verified with stem cell-derived cardiomyocytes provided by all leading stem cell providers, as beating 3D-clusters or monolayers, as well as with cell lines (cancer cells, hepatocyte-like cells, etc.) for cytotoxicity studies.