Fc gamma RIIA / CD32a Molecule Synonym Name
CD32a, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2
Fc gamma RIIA / CD32a Molecule Background
Receptors for the Fc region of IgG (Fc ¦Ã R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc ¦Ã Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
There are three genes for human Fc¦Ã RII /CD32 (A, B, and C) and one for mouse Fc¦Ã RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM.