Fc gamma RIIB / CD32b Molecule Synonym Name
FCGR2B, CD32b, CD32, FCG2, IGFR2, CDw32
Fc gamma RIIB / CD32b Molecule Background
Receptors for the Fc region of IgG (Fc ? R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc ? Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fc? RII /CD32 (A, B, and C) and one for mouse Fc? RII B (CD32B).
CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
Fc gamma RIIB / CD32b References