The Human Recombinant Carbonic Anhydrase (CA) 2 preserves acid-base balance in blood and other tissues.
The enzyme Carbonic anhydrase 2 (CA2) belongs to the enzyme group that catalyzes rapid inter-conversion of carbon dioxide and water to carbonic acid, bicarbonate, and protons (CO2 + H2O to HCO3 + H), a reaction that takes place rather gradually in the absence of a catalyst. The majority of carbonic anhydrases enclose a zinc ion in their active site and thus is categorized as metalloenzymes. The most critical function of Carbonic anhydrase is said to preserve acid-base balance in blood and other tissues, and to help convey carbon dioxide of tissues.
Carbonic anhydrases exist in areas of life. Mammalian carbonic anhydrase is monomeric and is a part of the alpha class. Mutations in the CA2 gene cause the CA2 deficiency syndrome, an autosomal recessive disorder that results in renal tubular acidosis, osteoporosis, and cerebral calcification.
Product Details
| Cat # +Size |
6390-100 |
| Size |
100 μg |
| Alternate Name |
CA-II, CAC, Carbonic anhydrase 2, Carbonate dehydratase 2, can, cynT2, yadF, b0126, JW0122, Carbonic Anhydrase II |
| Gene Symbol |
CA2 |
| Gene ID |
760 |
| Accession # |
P00918 |
| Source |
E. Coli |
| Appearance |
Liquid |
| Physical Form Description |
1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 50 mM NaCl, 1 mM DTT and 10% glycerol. |
| Molecular Weight |
29.2 kDa (260 aa, 1-260 aa) |
| Purity by SDS-PAGE |
≥95% |
| Biological Activity |
Specific activity is 50-70 nmoles/min/µg and was obtained by measuring the increase in the amount of p-nitrophenol by its esterase activity |
| Amino Acid Sequence |
MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP PLLECVTWIV LKEPISVSSE QVLKFRKLNF NG |
| Handling |
Centrifuge the vial prior to opening |
| Storage Conditions |
-20 °C |
| Shipping Conditions |
Gel Pack |
| Usage |
For research use only! Not to be used in humans |