Labskin is a full-thickness human skin equivalent that includes fully differentiated epidermal and dermal parts. These parts functionally model skin; thus, Labskin can be used to perform superior-quality skin research and testing.
Whether a user performs standard or applied skin research, or tests compounds or formulated products from the pharmaceutical, cosmetic, or chemical sectors, Labskin offers the user a convenient, high-quality, dependable, and reproducible living skin model.
- It is possible to colonize Labskin with skin microflora
- Labskin imitates real human skin biome for real-world results
Designed by Skin Scientists
Labskin was designed after 12 years of development work. Labskin has been engineered by skin scientists to offer a living skin equivalent with excellent longevity and robustness. It has a large surface area and high strength, making it ideal for a broad range of research and test applications.
Developed from metabolically active primary human fibroblasts and keratinocytes that carry out paracrine signaling, Labskin more closely replicates the in-vivo environment compared to monolayer cultures or ex-vivo skin models.
Designed for Skin Microbiology
Exceptional for a skin equivalent model, it is possible to colonize Labskin with the microflora of skin to offer a life-like platform for the analysis of microbiological systems or the impact of antimicrobials.
Users can use either identified pathogenic strains or commensal skin microflora to gauge cellular as well as microbial responses to a product, at the same time.
Dermatophytes (T. rubrum)—Antifungal effect in colonization of Labskin by Dermatophytes.
Malassezia globosa—Antidandruff effect in colonization of Labskin with Malassezia.
Malassezia globosa + Commensal Microflora—Antidandruff effect in colonization of Labskin with Malassezia and a commensal microbial consortium.
Staphylococci—Testing for dysbiosis in Eczema.
Acne vulgaris—Acne-related infection by C. acnes.
Wounds—Antiseptic/antimicrobial testing in wounds colonized by interkingdom biofilms (S. aureus + C. albicans).
Enhanced Barrier Function
As a fully differentiated, multi-layered human skin alternative with a comprehensive basement membrane, Labskin exhibits a barrier function akin to that of human skin.
Labskin’s dry surface offers a physical protective barrier to the cells underneath. Electrical impedance and Transepidermal Water Loss (TEWL), used to quantify the reliability of the skin’s barrier function, reveal Labskin is an outstanding model as an alternative to human skin.
Strong and Robust Tissue
Labskin feels, looks, and acts quite similar to human skin. Since its life-like surface is anchored and dry, it is considerably stronger and easier to manipulate, compared to other skin models available in the market.
Labskin has a surface area of 4.5 cm2 and has high strength, enabling realistic product application, for example, repeated finger-spreading. Labskin can be tested as one would in the clinic, enduring scrub-washing, tape-stripping, and several punch biopsies.
- Microbial colonization
- Basic and applied skin research
- Pre-clinical screening
- Product and ingredient efficiency
- Structural, metabolic, and physiological studies
- Penetration and delivery
- Gene and protein expression
- Large size facilitates numerous tests
- Fully differentiated and multi-layered skin model
- Metabolically active primary human skin cells
- Epidermal and dermal components
- De novo collagen production
- Skin-like surface and strength
- Easy to handle and ready to use
- Large test area (4.5 cm2)
- 10+ day test window
- Barrier function resembling native skin
- Uniform, superior-quality, and reproducible tissues
Labskin is built from pooled regular primary adult human fibroblasts, and neonatal foreskin primary human keratinocytes.
The novel construction technique of the dermis using polymerized fibrin to act as the supporting matrix considerably enhances strength and barrier integrity. Labskin can be naturally fastened to a plastic insert for ease of use and handling.
The whole dermal matrix is secreted by the fibroblasts in the dermal compartment, thus forming a completely natural and complicated mix of extracellular matrix (ECM) proteins.
The considerably enhanced robustness renders Labskin compatible with several standard applications and sampling procedures. This enables it to be used in a broader range of applications compared to other models.