LILRA2 Molecule Synonym Name
ILT1, LIR7, CD85H, LIR-7, LILRA2, ILT1CD85H, CD85h, ILT1, ILT-1, ILT1CD85H, CD85h antigen, CD85 antigen-like family member H
LILRA2 Molecule Background
LILRA2 (Leukocyte immunoglobulin like receptor A2), also known as CD85H and LIR7 (Leukocyte immunoglobulin-like receptor 7). It belongs to the subfamily A class of LIR receptors (LILRAs), which are single-pass type I transmembrane proteins with 2-4 extracellular Ig-like domains, a transmembrane domain (TM), and a short cytoplasmic tail.
LILRA2 contains 4 Ig-like C2 type domains in the extracellular region. LILRA2 does not bind class I MHC antigens. LILRA2 is expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. LILRA2 is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response.
- Hirayasu K., et al., 2016, Nat Microbiol.,1(6), 16054.
- Brown D., et al., 2004, Tissue Antigens.,64(3), 215-25.
- MacGlashan DW Jr1., et al.,2008, J Immunol., 180(6), 4208-17.