Microwave Peptide Synthesis

Overview

The Liberty PRIME peptide synthesizer is a cutting-edge instrument for microwave peptide synthesis. Due to its innovative one-pot deprotection and coupling process it achieves a remarkable 2 minute cycle time with only 8.5 mL waste per cycle (at 0.1 mmol).

Unique Chemistry

  • One-pot coupling and deprotection chemistry (patented)
  • CarboMAX™ coupling chemistry (patented)
  • Microwave deprotection and coupling (patented)

Features

  • Unparalleled 2 min cycle time
  • Unrivaled 8.5 mL waste per cycle at (0.1 mmol)
  • Automated synthesis of up to 24 peptides
  • Precise calibration-free delivery of all reagents
  • Integrated Camera (optional)

Synthesize 20mer’s Every 45 Minutes.

Thanks to an innovative one-pot deprotection and coupling process and the patented CarboMAX coupling chemistry, a revolutionary 2 minute cycle time is achieved.

Reduce SPPS Chemical Waste to Unbelievable Levels

The Liberty PRIME employs a patented process to reuse the coupling solution for the subsequent deprotection step. In addition, the system is designed such that it does not require any internal washing. This significantly reduces the waste production.

No Calibration is Needed

The reagents can be delivered either by pressure-based Flex-Add delivery system or a precalibrated pumping system.

Therefore, the correct amount of each reagent is delivered every time down to volumes as low as 0.25 mL. This calibration-free reagent delivery is perfect for GMP processes.

The Best Coupling Method for Peptide Synthesis

  • The fastest and most complete coupling
  • Stabilizes acid sensitive linkages which are problematic for standard carbodiimide chemistry (phospho, glyco, hyper-acid linkages)
  • Unmatched low-level of epimerization for all 20 amino acids due to faster activation (faster o-acylisourea formation)

Synthesize Standard and Complex Peptides.

  • Branched Peptides
  • Cyclized Peptides
  • Disulfide Bonding
  • Glycopeptides (N/O-linked)
  • High Throughput Synthesis
  • N-Methyl Peptides
  • Peptide Thioesters
  • Peptoids
  • Phosphopeptides
  • PNA

Cleave Batches of Peptides in only 30 Minutes.

The Razor is the perfect companion for the Liberty PRIME. It cleaves peptides in just 30 minutes while protecting your synthesizer from volatile TFA fumes.