The Neopterin ELISA from Tecan offers users a sensitive test to quantify neopterin, which acts as an initial warning system of infection in the body. Neopterin can act as a biomarker for infection of the body by attacking pathogens. Recent study indicates that it can help assess the severity of a SARS-CoV-2 infection.1,2

Schematic time course of neopterin concentration in blood, in relation to antibody presence due to viral infection

Figure 1. Schematic time course of neopterin concentration in blood, in relation to antibody presence due to viral infection.3 Image Credit: Tecan

Main advantages of Tecan Neopterin ELISA

  • Early detection of a current infection in the body
  • Regulatory status Europe: CE*
  • Bacterial and viral infections can be detected
  • Good correlation with HPLC (serum r = 0.92; urine r = 0.99)
  • Validated for urine, plasma (EDTA) and serum
  • Entire testing procedure, including results, can be completed within two hours
  • Can be utilized automated or manually on open-format ELISA processors**

*The combined use of assay, process script and instrument should be individually validated on site by each laboratory.

**The product may not be available in users’ area. They can contact their local Tecan representative.

References

  1. Evaluation of the severity of an COVID-19 infection (Ozger et al, 2020; Hailemichael et al., 2021).
  2. Differential diagnosis between viral and bacterial infections (Murr et al., 2002; Plata-Nazar et al., 2015).
  3. Schennach H, et al. Increased prevalence of IgM antibodies to Epstein-Barr virus and parvovirus B19 in blood donations with above-normal neopterin. Clinical Chemistry, 1994, 40, 2104. doi.org/10.1128/CVI.00380-08.