PCSK9 Molecule Information
Name：Proprotein convertase subtilisin kexin type 9
Target Synonym：Neural apoptosis-regulated convertase 1?Proprotein convertase 9?Proprotein convertase subtilisin/kexin type 9?NARC1?Subtilisin/kexin-like protease PC9?NARC-1?PCSK9?PC9
Number of Launched Drugs：2
Number of Drugs in Clinical Trials：22
Lastest Research Phase：Approved
PCSK9 Molecule Synonym Name
PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9
PCSK9 Molecule Background
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis.
PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
PCSK9 Related Molecule