PD-L1 Molecule Information
Name：Programmed death-ligand 1
Target Synonym：Programmed death ligand 1?B7 homolog 1?CD_antigen=CD274?Programmed cell death 1 ligand 1?B7H1 ?PDCD1L1?PDCD1LG1?CD274?PD-L1?B7-H1?PDL1?PDCD1 ligand 1
Number of Launched Drugs：3
Number of Drugs in Clinical Trials：36
Lastest Research Phase：Approved
PD-L1 Molecule Synonym Name
PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
PD-L1 Molecule Background
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.
B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver.
PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.